首页> 外国专利> Anaplastic lymphoma kinase (ALK) as an oncogene capable of transforming normal human cells

Anaplastic lymphoma kinase (ALK) as an oncogene capable of transforming normal human cells

机译:间变性淋巴瘤激酶(ALK)是一种能够转化正常人细胞的致癌基因

摘要

The present invention provides compositions and methods for transforming primary mammalian cells using an oncogenic form of ALK wherein the transformed cells display features of that of a corresponding tumor cell isolated from a cancer subject. The invention also provides a method for immortalizing normal CD4+ T lymphocytes with a lymphoma-characteristic form of ALK such as NPM-ALK.
机译:本发明提供了使用致癌形式的ALK转化原代哺乳动物细胞的组合物和方法,其中转化的细胞显示出从癌症受试者中分离出的相应肿瘤细胞的特征。本发明还提供了用具有淋巴瘤特征形式的ALK例如NPM-ALK永生化正常CD4 + T淋巴细胞的方法。

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