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Anaplastic lymphoma kinase (ALK) as an oncogene capable of transforming normal human cells
Anaplastic lymphoma kinase (ALK) as an oncogene capable of transforming normal human cells
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机译:间变性淋巴瘤激酶(ALK)是一种能够转化正常人细胞的致癌基因
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摘要
The present invention provides compositions and methods for transforming primary mammalian cells using an oncogenic form of ALK wherein the transformed cells display features of that of a corresponding tumor cell isolated from a cancer subject. The invention also provides a method for immortalizing normal CD4+ T lymphocytes with a lymphoma-characteristic form of ALK such as NPM-ALK.
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