首页> 外国专利> Preparation of ambrox from labdanes of Dysoxylum hongkongense, and the preparation of new diterpenoids from Dysoxylum hongkongense

Preparation of ambrox from labdanes of Dysoxylum hongkongense, and the preparation of new diterpenoids from Dysoxylum hongkongense

机译:香椿(I. Dysoxylum hongkongense)的拉丹烷中氨溴环的制备以及香椿(I. Dysoxylum hongkongense)的新二萜类化合物的制备

摘要

The present invention discloses eight new diterpenoids, i.e. Dysongensins A to H, extracted from the leaves and twigs of Dysoxylurn hongkongense, wherein AMBROX® which is applicable in the perfume industry is prepared from Dysongensin A via a series of chemical reactions, and the cytotoxicity of Dysongensins A to H against human cancer cell lines and their antiviral and anti-inflammatory activities are determined. Therefore, in the present invention, AMBROX® prepared from Dysongensin A is a new idea for application as an odorous compound in the perfume industry, and the novel diterpenoids can be prepared as a pharmaceutical compositions and/or a drug having antiviral, anti-inflammatory and/or anti-cancer activities.
机译:本发明公开了从香豆素的叶和嫩枝中提取的八种新的二萜类化合物,即强生素A至H。其中,适用于香料工业的AMBROX®是由强生素A通过一系列确定化学反应,强生素A对H的抗人癌细胞毒性及其抗病毒和抗炎活性。因此,在本发明中,由Dysongensin A制备的AMBROX®是在香料工业中用作气味化合物的新思路,并且可以将新型二萜类化合物制备为药物组合物和/或具有抗病毒,抗炎作用的药物和/或抗癌活动。

著录项

  • 公开/公告号US9260404B1

    专利类型

  • 公开/公告日2016-02-16

    原文格式PDF

  • 申请/专利权人 NATIONAL TAIWAN UNIVERSITY;

    申请/专利号US201414548374

  • 发明设计人 YA-CHING SHEN;

    申请日2014-11-20

  • 分类号C07D307/92;C07C45/78;C07C49/743;

  • 国家 US

  • 入库时间 2022-08-21 14:31:26

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