首页>
外国专利>
Boosting human dendritic cell development, homeostasis and function in xenografted immunodeficient mice
Boosting human dendritic cell development, homeostasis and function in xenografted immunodeficient mice
展开▼
机译:促进异种移植免疫缺陷小鼠的人树突状细胞发育,体内稳态和功能
展开▼
页面导航
摘要
著录项
相似文献
摘要
The present invention relates to a transgenic animal model system based on the development of transgenic mice bearing components of the human immune system. Specifically, the invention relates to a Flk2 deficient Rag−/−γc−/− transgenic mouse and the engraftment of said mouse with human hematopoietic stem cells. The present invention further provides methods for increasing the numbers of functionally competent human dendritic cells and the hematopoietic targets cells that they interact with in said transgenic mouse through the administration of Flk2L. The transgenic animal model system of the invention may be used for testing human vaccine candidates, for screening potential immune adjuvants and for developing novel therapeutics.
展开▼