首页> 外国专利> Boosting human dendritic cell development, homeostasis and function in xenografted immunodeficient mice

Boosting human dendritic cell development, homeostasis and function in xenografted immunodeficient mice

机译:促进异种移植免疫缺陷小鼠的人树突状细胞发育,体内稳态和功能

摘要

The present invention relates to a transgenic animal model system based on the development of transgenic mice bearing components of the human immune system. Specifically, the invention relates to a Flk2 deficient Rag−/−γc−/− transgenic mouse and the engraftment of said mouse with human hematopoietic stem cells. The present invention further provides methods for increasing the numbers of functionally competent human dendritic cells and the hematopoietic targets cells that they interact with in said transgenic mouse through the administration of Flk2L. The transgenic animal model system of the invention may be used for testing human vaccine candidates, for screening potential immune adjuvants and for developing novel therapeutics.
机译:本发明涉及基于带有人免疫系统组分的转基因小鼠的发展的转基因动物模型系统。具体地,本发明涉及Flk2缺陷的Rag -/-γc-/-转基因小鼠,以及所述小鼠与人类造血干细胞的移植。本发明进一步提供了通过施用Flk2L来增加在所述转基因小鼠中相互作用的功能上有能力的人树突细胞和造血靶细胞的数量的方法。本发明的转基因动物模型系统可用于测试人疫苗候选物,用于筛选潜在的免疫佐剂和用于开发新的疗法。

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