首页> 外国专利> Analyzing Immune Signaling Networks for Identification of Therapeutic Targets in Complex Chronic Medical Disorders, Identification of a Natural Killer Cell Population as a Potential Therapeutic Target for Gulf War Illness And Myalgic Encephalomyelitis/Chronic Fatigue Syndrome, And Modulation of Natural Killer Cell Function by Stimulation with Interleukin 15

Analyzing Immune Signaling Networks for Identification of Therapeutic Targets in Complex Chronic Medical Disorders, Identification of a Natural Killer Cell Population as a Potential Therapeutic Target for Gulf War Illness And Myalgic Encephalomyelitis/Chronic Fatigue Syndrome, And Modulation of Natural Killer Cell Function by Stimulation with Interleukin 15

机译：分析免疫信号网络以鉴定复杂的慢性医学疾病的治疗靶标，鉴定天然杀伤细胞作为海湾战争疾病和肌炎性脑脊髓炎/慢性疲劳综合症的潜在治疗靶标，并通过白介素刺激调节自然杀伤细胞功能15

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摘要

A general method of analyzing immune signaling networks for identification of potential therapeutic targets in complex, chronic medical disorders is described. The disclosure provides the CD3−/CD56+ natural killer (NK) cell population as a potential therapeutic target in the clinically-overlapping disorders Gulf War Illness (GWI) and Myalg Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS). The disclosure also provides a method for improving or restoring Natural Killer (NK) cell function by stimulating the NK cells with interleukin-15 (IL-15).

机译：描述了分析免疫信号网络以鉴定复杂的慢性医学疾病中潜在治疗靶标的一般方法。本公开提供了CD3- / CD56 +自然杀伤（NK）细胞群体作为在临床上重叠的疾病海湾战争疾病（GWI）和Myalg脑脊髓炎/慢性疲劳综合症（ME / CFS）中的潜在治疗靶标。本公开还提供了一种通过用白介素-15（IL-15）刺激NK细胞来改善或恢复自然杀伤（NK）细胞功能的方法。

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公开/公告号US2016275236A1

专利类型
公开/公告日2016-09-22

原文格式PDF
申请/专利权人 NOVA SOUTHEASTERN UNIVERSITY;
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申请/专利号US201415028757
发明设计人 MARY ANN FLETCHER;GORDAN BRODERICK;NANCY KLIMAS;ZACHARY BARNES;
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申请日2014-10-14
分类号G06F19/12;A61K38/20;
国家 US
入库时间 2022-08-21 14:37:35

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