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CONSTRUCTION OF MITOCHONDRIAL UQCRB MUTANT EXPRESSING CELLS AND UTILIZATION OF THE CELLS FOR UQCRB ASSAY SYSTEM THEREOF
CONSTRUCTION OF MITOCHONDRIAL UQCRB MUTANT EXPRESSING CELLS AND UTILIZATION OF THE CELLS FOR UQCRB ASSAY SYSTEM THEREOF
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机译：线粒体UQCRB突变体表达细胞的构建及其在UQCRB检测系统中的应用
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摘要
The present invention relates to a mitochondrial UQCRB mutant cell line expressing the UQCRB mutant protein. The present invention is directed to a novel research method for UQCRB activity evaluation using a novel mitochondrial UQCRB mutant cell line, and provides a method for anticancer activity evaluation, a method for angiogenesis inhibitory activity evaluation, and a method for screening a UQCRB activity inhibitor. In particular, the cell line of the present invention is a novel cell line having cell proliferative and angiogenesis inducing activities, and provides a method for screening an angiogenesis inhibitor or an anticancer material through the UQCRB activity inhibitory mechanism, and thus can be applied in the development of therapeutic agents against angiogenesis or mitochondria-mediated diseases and various cancers.
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