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Process for producing glycoproteins characterized by sugar chain structure using silkworms
Process for producing glycoproteins characterized by sugar chain structure using silkworms
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机译:用蚕生产具有糖链结构特征的糖蛋白的方法
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摘要
It is an object of the present invention to investigate what kinds of structures a sugar chain has by performing a sugar chain structural analysis of a glycoprotein produced in a transgenic silkworm. For the sugar chain of the glycoprotein produced in the transgenic silkworm, a glycoprotein having a sugar chain structure in which fucose is not linked to N-acetylglucosamine at a reducing terminal of the sugar chain is obtained. In addition, a glycoprotein having an almost completely humanized sugar chain structure is obtained by further integrating GalT gene into this transgenic silkworm.
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