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Prediction method of anticancer drug response and prognosis based on the disease type classification of colon cancer by gene expression analysis
Prediction method of anticancer drug response and prognosis based on the disease type classification of colon cancer by gene expression analysis
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机译:基于基因表达分析的基于结肠癌疾病类型分类的抗癌药物反应和预后预测方法
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摘要
PROBLEM TO BE SOLVED: To provide a method for integrally analyzing mutation of genes or the like corresponding to carcinogenesis of colon cancer based on comprehensive analysis of gene expressions of colon cancer.SOLUTION: There are provided a method for predicting responsiveness of an anti EGFR antibody or anticancer drug of a colon cancer patient comprising a process (1) of measuring expressions of cluster A gene, cluster B gene, cluster 1 gene, and cluster 2 gene, (2) a process of obtaining the coefficient of correlation between individual expression profiles of individual clusters obtained from the expressions and mean expression profile of the previously obtained individual clusters, and (3) a process of relegating the sample to a cluster having a larger coefficient of correlation between the average expression profile and cluster A and between the average expression profile and cluster B, and to a cluster having a larger coefficient of correlation between the average expression profile and cluster 1 and between the average expression profile and cluster 2.
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