首页> 外国专利> SYNTHETIC OLIGOPEPTIDES DESIGNED FROM MITE CYSTEINE PROTEASES AND METHODS FOR THE PRODUCTION OF IGY POLYCLONAL ANTIBODIES FOR THE DETECTION OF INTRADOMICILIARY MITES

SYNTHETIC OLIGOPEPTIDES DESIGNED FROM MITE CYSTEINE PROTEASES AND METHODS FOR THE PRODUCTION OF IGY POLYCLONAL ANTIBODIES FOR THE DETECTION OF INTRADOMICILIARY MITES

机译：由螨半胱氨酸蛋白酶设计的合成寡肽以及用于检测肌内MI虫的IGy多克隆抗体的生产方法

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摘要

The invention refers to the design, synthesis and evaluation of 6 synthetic oligopeptides, that have not been previously described, designed from the T and B epitopes of allergens of group I of intradomiciliary mites of the species Dermatophagoides pteronyssinus, Dermatophagoides farinae and Blomia tropicalis, which can be used in the immunomodulation of individuals having immunocompetent systems and in the production of IgY polyclonal antibodies. The invention relates to a first method for obtaining a composition of IgY polyclonal antibodies that can be used as a diagnostic reagent having low cost and high reactivity in respect of intradomiciliary mites, and a second method for the detection of mite allergens, using the IgY antibody composition developed in the first method. The invention further relates to the composition of the IgY polyclonal antibodies.

机译：本发明涉及从Dermatophagoides pteronyssinus，Dermatophagoides farinae和Blomiatropicis属的螨虫的第一组过敏原的T和B表位设计的6种合成寡肽的设计，合成和评估，这些寡肽以前没有被描述。可以用于具有免疫活性系统的个体的免疫调节和IgY多克隆抗体的产生。本发明涉及用于获得IgY多克隆抗体组合物的第一方法，该组合物可以用作成本低且对家蝇内螨具有高反应性的诊断试剂，以及用于检测螨过敏原的第二种方法，使用该IgY抗体第一种方法开发的成分。本发明进一步涉及IgY多克隆抗体的组成。

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公开/公告号EP2431381B1

专利类型
公开/公告日2016-10-12

原文格式PDF
申请/专利权人 FUNDACION UNIVERSIDAD DEL NORTE;PONTIFICIA UNIVERSIDAD JAVERIANA;
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申请/专利号EP20100789072
发明设计人 EGEA EDUARDO;BARRERA LUIS ALEJANDRO;ESPEJO JOHANA;SOSA CATALINA;NAVARRO ELKIN;GARAVITO GLORIA;MENDOZA DARY LUZ;
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申请日2010-03-17
分类号C07K7/08;C07K16/18;A61K39/35;C07K14/435;
国家 EP
入库时间 2022-08-21 14:53:18

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