首页> 外国专利> STRAIN O №2102/Zabaikalsky/2010 FMD VIRUS Aphtae epizooticae OF TYPE O FOR CONTROL OF ANTIGENIC AND IMMUNOGENIC ACTIVITY OF FMD VACCINES AND FOR PRODUCTION OF BIOLOGICAL PRODUCTS FOR DIAGNOSTICS AND SPECIFIC PROPHYLAXIS OF FMD OF TYPE O

STRAIN O №2102/Zabaikalsky/2010 FMD VIRUS Aphtae epizooticae OF TYPE O FOR CONTROL OF ANTIGENIC AND IMMUNOGENIC ACTIVITY OF FMD VACCINES AND FOR PRODUCTION OF BIOLOGICAL PRODUCTS FOR DIAGNOSTICS AND SPECIFIC PROPHYLAXIS OF FMD OF TYPE O

机译：菌株O№2102/ Zabaikalsky / 2010 O型口蹄疫病毒口疮流行病菌，用于控制口蹄疫疫苗的抗原和免疫原性活性，以及生产用于O型口蹄疫的诊断产品和特定前身生物制品

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FIELD: biotechnology.;SUBSTANCE: proposed strain is reproduced in a monolayer culture of pig kidney cells (PK), passaged cultures PSGK-30, BHK-21 and IBRS-2, for 18-24 hours of incubation the virus yield in these cell cultures reaches the values of 6.63-7.5 lg TCD 50/cm³. At high multiplicity of infection (1-10 TCD/cell) it causes TCD after 5 hours, while maintaining the initial characteristics in passaging in cell cultures for 10 passages.;EFFECT: strain may be used to control the antigenic and immunogenic activity of FMD vaccines and for production of biological products for diagnostics and specific prevention of FMD of type O.;6 cl, 1 dwg, 8 tbl, 9 ex

机译：领域：生物技术;研究对象：拟定的菌株在猪肾细胞（PK），PSGK-30，BHK-21和IBRS-2的传代培养物中培养18-24小时，在这些细胞中的病毒产量培养物达到6.63-7.5 lg TCD 50 / cm ^{3 的值。在高感染复数（1-10 TCD /细胞）下，它会在5小时后引起TCD，同时在细胞培养中传代的初始特征保持10代。;效果：菌株可用于控制FMD的抗原和免疫原活性疫苗和用于诊断和特异性预防O型口蹄疫的生物制品生产; 6 cl，1 dwg，8 tbl，9 ex}

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公开/公告号RU2563522C1

专利类型
公开/公告日2015-09-20

原文格式PDF
申请/专利权人 FEDERALNOE GOSUDARSTVENNOE BJUDZHETNOE UCHREZHDENIE FEDERALNYJ TSENTR OKHRANY ZDOROVJA ZHIVOTNYKH (FGBU VNIIZZH);
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申请/专利号RU20140132227
发明设计人 DRYGIN VLADIMIR VIKTOROVICH;KONSTANTINOV ALEKSEJ VLADIMIROVICH;MIKHALISHIN DMITRIJ VALEREVICH;MISHCHENKO ALEKSEJ VLADIMIROVICH;SHCHERBAKOV ALEKSEJ VLADIMIROVICH;MISHCHENKO VLADIMIR ALEKSANDROVICH;RUMJANTSEVA OLGA SERGEEVNA;KREMENCHUGSKAJA SVETLANA REVDITOVNA;NIKIFOROV VIKTOR VIKTOROVICH;MAJOROVA TAMARA KONSTANTINOVNA;
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申请日2014-08-06
分类号C12N7/00;C12R1/93;
国家 RU
入库时间 2022-08-21 14:56:07

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