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METHOD OF TREATING LOCALLY ADVANCED OROPHARYNGEAL CANCER

机译：局部晚期口腔癌的治疗方法

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FIELD: medicine.;SUBSTANCE: treating locally advanced oropharyngeal cancer is ensured by a radiation therapy in the mode of dynamic dose fractionation. The radiation therapy is started by supplying a fraction dose of 2.4 Gy. After 2 days of treatment gap, the patient is exposed to total fractions at a fraction dose of 3.6Gy for three days. Each session is precede by placing high-structure hydrogel matrix of sodium alginate under a patient's tongue with metronidazole 150mg and bilberry 20-35mg pre-introduced into the matrix, for 4-5 hours twice every 1-2 hours. The two following sessions of the exposure at a fraction dose of 2.4 Gy are preceded by placing the matrix once under the tongue for 4-5 hours. After 2 days of treatment gap, the following 5 sessions of the radiation therapy are performed at a fraction dose of 2.4 Gy to a cumulative dose of 30Gy. Colegel-DNA-Ch high-structure disk is preliminary placed under the tongue for 4-5 hours.;EFFECT: method enables avoiding the compulsory gaps of the radiation therapy by reducing a rate of severe local radiation reactions, and provides the target delivery and accurate dosage of metronidazole administered into the patient's body leading to the partial death of well-oxygenated cells and re-oxygenation of hypoxic tumour cells.;2 ex
机译：领域：医学;;物质：通过放射疗法以动态剂量分级的方式确保治疗局部晚期口咽癌。通过提供2.4 Gy的剂量剂量开始放射治疗。在治疗间隔2天后，患者以3.6Gy的分次剂量暴露于总级分中三天。每次治疗前，将海藻酸钠的高结构水凝胶基质置于患者的舌头下，将甲硝唑150mg和越桔20-35mg预先引入基质中，每1-2小时两次，每次4-5小时。在以剂量为2.4 Gy的剂量进行两次暴露之后，将基质一次置于舌下4-5小时。在治疗间隔2天后，以2.4 Gy的剂量剂量至30 Gy的累积剂量进行接下来的5次放射治疗。将Colegel-DNA-Ch高结构盘预先放置在舌下4-5小时。效果：该方法可通过降低严重的局部放射反应的发生率来避免放射治疗的强制性缺口，并提供靶点递送和准确剂量的甲硝唑施用于患者体内，导致氧合良好的细胞部分死亡，低氧肿瘤细胞再次氧合。

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