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DIAGNOSTIC TECHNIQUE FOR CELL DYSIMMUNITY IN CHEMICAL WORKERS EXPOSED TO FORMALDEHYDE

机译:甲醛接触化学工人细胞失代的诊断技术。

摘要

FIELD: medicine.;SUBSTANCE: invention refers to medicine and immunology, and aims at identifying the unfavourable exposure of formaldehyde on the human body, namely on the cell immunity. The substance of the method: venous blood is sampled from the workers, measuring the formaldehyde concentration and lymphocyte count that are basic parameters of the T-cell immunity; that is followed by stating a criterion that shows the cell dysimmunity. Basic parameters of the T-cell immunity are a percentage of activated T-lymphocytes CD3+CD95+ and also a percentage of T-regulatory lymphocytes CD4+CD25+CD127-; the criterion is an integrated index equal to CD3+CD95+ /CD4+CD25+CD127- lymphocytes ratio. If the integrated index is 40 or more, the cell dysimmunity is diagnosed in the chemical workers exposed to formaldehyde.;EFFECT: using the invention provides the higher information value of the assessment of the xenobiotic (formaldehyde) exposure on the cell dysimmunity in the chemical workers' bodies.;2 tbl, 2 ex
机译:技术领域本发明涉及医学和免疫学,并且旨在鉴定甲醛对人体的不利暴露,即对细胞免疫性。方法的实质:从工人那里抽取静脉血,测量甲醛浓度和淋巴细胞计数,这是T细胞免疫的基本参数;然后说明显示细胞免疫不良的标准。 T细胞免疫的基本参数是活化的T淋巴细胞CD3 + CD95 + 的百分比,以及T调节性淋巴细胞CD4 + CD25 + CD127 -;标准是等于CD3 + CD95 + / CD4 + CD25 + CD127 -淋巴细胞比率的综合指数。如果综合指数为40或更高,则在接触甲醛的化学工作者中诊断出细胞免疫障碍。效果:使用本发明提供了评估异种(甲醛)暴露对化学物质中细胞免疫障碍的较高信息价值。工人的身体。; 2 tbl,2 ex

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