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METHOD OF TREATING AND MANAGING PREGNANT WOMEN WITH DRUG-INDUCED HEPATITIS
METHOD OF TREATING AND MANAGING PREGNANT WOMEN WITH DRUG-INDUCED HEPATITIS
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机译：药物性肝炎治疗和处理孕妇的方法
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FIELD: medicine.;SUBSTANCE: invention refers to medicine, namely to obstetrics and gynaecology, and can be used for treating and managing the pregnant women suffering drug-induced hepatitis. Establishing a diagnosis of drug-induced hepatitis requires oral administration of the herbal hepatoprotectors Carsil, or Hepabene, or the vitamin-free essential phospholipids Eslidin per os or Essentiale forte N intravenously, per os in standard doses with a cessation of any other drug-induced therapy, in the 1st trimester of pregnancy in case of observing a symptom-free increase of transaminase activity within 3 normal values and no counter-indications. In the 2nd trimester, a serum transaminase level up to 5 normal values requires prescribing ademetionine 400 mg intravenously N 7-10, then per os 1,600 mg/day. The therapeutic course makes 1 month. Ademetionine 800 mg intravenously N 10 + ursodeoxycholic acid 12 mg/kg/day are prescribed if observing the daily serum transaminase level of 5 to 10 normal values. Prescribing ademetionine 800 mg/day intravenously + ursodeoxycholic acid 12 mg/kg/day + prednisolone 90 mg/day is used for the daily serum transaminase level of more than 10 normal values. In the 3rd trimester, the daily serum transaminase level of below 5 normal values requires administering ademetionine 800 mg/day intravenously N10 + ursodeoxycholic acid 13 mg/kg/day. The transaminase level of 5 to 10 normal values requires prescribing ademetionine 800 mg/day intravenously + ursodeoxycholic acid 13 mg/kg/day + prednisolone 90 mg/day intravenously. A progressive increase of the daily transaminase level of above 10 normal values with underlying therapy with ademetionine 800 mg/day intravenously, ursodeoxycholic acid 13 mg/kg/day, prednisolone 120 mg/day intravenously with 3 days expected, a decrease of the daily transaminase level or a stabilization thereof are accompanied by continuing the therapy with the progression follow-up, including hepatic cytolysis values - an increase of the hepatic cytolysis values; an increase thereof is accompanied by prescribing the adequate therapy. The postpartum therapy is continued completely until liver function tests are normalised.;EFFECT: method enables preventing the pregnancy complications ensured by the timely diagnosis of drug-induced hepatitis in the pregnant women, the adequate drug-induced therapy differentiated by gestational age and a degree of manifestation of hepatic cytolysis and aiming at reducing a hepatic pathological process.;6 ex
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机译：领域：药物。发明：本发明涉及药物，即涉及妇产科，并且可以用于治疗和治疗药物性肝炎的孕妇。要确定药物诱发的肝炎，需要口服口服口服口服口服口服口服口服口服口服口服口服口服草药草药保肝剂Carsil或Hepabene或不含维生素的必需磷脂Eslidin Eslidin或口服Essentials forteN。在妊娠的第一三个月中观察到转氨酶活性无症状增加，且在3个正常值范围内，并且没有任何适应症。在第2 孕中期，血清转氨酶水平达到5个正常值时，需要静脉注射N- 7-10的阿德美汀400 mg，然后口服os 1,600 mg / day。治疗过程为1个月。如果观察到的每日血清转氨酶水平为正常值的5到10，则建议静脉注射Ademetionine 800 mg N 10 +熊去氧胆酸12 mg / kg /天。每日血清转氨酶水平超过10正常值时，静脉使用阿德美汀800 mg /天+熊去氧胆酸12 mg / kg /天+泼尼松龙90 mg /天。在第三 rd 孕中期，每日血清转氨酶水平低于正常值5时，需要静脉注射N10 +熊去氧胆酸13 mg / kg /天，静脉注射ademetionine 800 mg /天。转氨酶水平为5到10正常值时，需要静脉注射阿美丁汀800 mg /天+熊去氧胆酸13 mg / kg /天+泼尼松龙90 mg /天。通过基础治疗，静脉注射阿美丁汀800 mg /天，熊去氧胆酸13 mg / kg /天，泼尼松龙120 mg /天的基础疗法，每日转氨酶水平逐渐升高至10个正常值以上，预计3天，每日转氨酶减少水平或其稳定伴随着继续进行包括随访在内的继续治疗，包括肝细胞溶解度值-肝细胞溶解度值的增加;其增加伴随着处方适当的治疗。产后治疗将完全继续进行，直到肝功能检查正常为止。效果：该方法能够预防妊娠并发症，方法是及时诊断孕妇的药物性肝炎，并根据胎龄和程度来区分适当的药物治疗肝细胞溶解的表现，旨在减少肝脏病理过程。; 6 ex
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