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APPLICATION OF AGONISM ANTIBODIES AGAINST CD83 FOR TREATMENT OF AUTOIMMUNE DISEASES
APPLICATION OF AGONISM ANTIBODIES AGAINST CD83 FOR TREATMENT OF AUTOIMMUNE DISEASES
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机译：抗CD83的单克隆抗体在自身疾病治疗中的应用。
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摘要
1. A method of treating or preventing an autoimmune disease in an individual, comprising administering to the individual an effective amount of an anti-CD83 agonist antibody. The method of claim 1, wherein the autoimmune disease is selected from the group consisting of rheumatoid arthritis, juvenile rheumatoid arthritis, systemic lupus erythematosus (SLE), lupus nephritis, ulcerative colitis, Wegener's disease, inflammatory bowel disease, idiopathic thrombocytopenic (ITP) purpurea. thrombotic thrombocytopenic purpura (TTP), autoimmune thrombocytopenia, multiple sclerosis, psoriasis, IgA nephropathy, IgM polyneuropathy, myasthenia gravis, vasculitis, diabetes mellitus, Raynaud's syndrome, Sheg syndrome Rena and glomerulonephritis. 3. The method of claim 1, wherein the autoimmune disease is associated with the activation of myeloid cells. The method of claim 3, wherein the individual suffers from Crohn’s disease. The method of claim 3, wherein the individual suffers from ulcerative colitis. The method according to any one of paragraphs. 1-5, in which the individual is a man. 7. The method according to any one of paragraphs. 1-5, wherein the anti-CD83 agonist antibody inhibits the release of the pro-inflammatory cytokine from mature dendritic cells. The method of claim 7, wherein the release of the pro-inflammatory cytokine MCP-1 and / or IL-12p40.9 is inhibited. The method according to any one of paragraphs. 1-5, wherein the anti-CD83 agonist antibody causes the release of an anti-inflammatory cytokine from mature dendritic cells. The method of claim 9, wherein the release of the anti-inflammatory cytokine IL-1ra is induced. The method according to any one of paragraphs. 1-5, in which an agonistic antibody against CD83 causes a decrease in the expression of CD83 and / and
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