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A method of predicting the results of treatment of infertility and pregnancy loss in women depending on immunological and immunogenetic INDICATORS

机译:根据免疫学和免疫原性指标预测女性不育和妊娠流失的治疗结果的方法

摘要

A method of predicting treatment outcome of infertility and miscarriage in females, depending on immunological and immunogenetic parameters comprising determining characteristics genotype HLA partners and donor lymphocytes, wherein the need of typing of HLA donor for limfotsitoterapii against high levels of NK-cells in the recipient, which improves the prognosis since it allows to immunize the maximum number of genes and to determine forecast zones using multivariate discriminant analysis, wherein the calculated values ​​of the canonical discriminant functions F1 and F2 for the pair with the HLA-compatible history, allowing include a pair 1, 2nd or 3rd zone on territorial map and determining a prognostic index P, when P 1,461, steam relates to the first zone - favorable prognosis of pregnancy, at P -1.237, steam in the third zone - a poor prognosis, with P in the range of -1.237, but 1,461, the couple belongs to the 2nd zone on a territorial map conditionally favorable prognosis (achieving pregnancy by methods support only p productive technologies).
机译:一种根据免疫学和免疫遗传学参数预测女性不育和流产治疗结果的方法,包括确定特征基因型HLA伴侣和供体淋巴细胞,其中需要针对接受者中高水平的NK细胞对limfotsitoterapii进行HLA供体分型,由于它允许免疫最大数量的基因并使用多变量判别分析确定预测区域,因此改善了预后,其中具有HLA兼容历史记录的对的标准判别函数F1和F2的计算值包括区域地图上的一对1、2或3区,并确定预后指数P,当P> 1,461时,蒸汽与第一区有关-妊娠的有利预后,在P <-1.237时,第三区中的蒸气对患者-预后不良,且P的范围> -1.237,但<1,461,这对夫妇属于领土地图上的第二个区域,有条件地预后良好(a通过方法进行怀孕仅支持生产技术)。

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