首页> 外国专利> - pH pH sensitive anticancer prodrug that is 2'-benzoyloxycinnamaldehyde-polyethylene glycol micelle carrying zinc protoporphyrin and method for preparing the same

- pH pH sensitive anticancer prodrug that is 2'-benzoyloxycinnamaldehyde-polyethylene glycol micelle carrying zinc protoporphyrin and method for preparing the same

机译:-pH值pH敏感的抗癌前药,其是带有锌原卟啉的2'-苯甲酰氧基肉桂醛-聚乙二醇胶束及其制备方法

摘要

The present invention relates to a pH-sensitive anticancer prodrug drug carrying zinc protoporphyrin on a benzoyloxycinnamic aldehyde-polyethylene glycol-bonded micelle. The pH-responsive anticancer prodrug drug carrying zinc protoporphyrin on the benzoyloxycinnamaldehyde-polyethylene glycol-bonded micelle of the present invention degrades the antioxidant level in cancer cells by releasing ZnPP while being decomposed by acidic pH, (ROS) is generated and accumulated by the release of benzyloxycinnamaldehyde, thereby promoting apoptosis. Thus, it has an excellent effect of causing a synergistic anticancer effect through double stimulation reaction and sequential treatment in a cancer cell-specific manner And can be useful as anticancer drugs and anticancer drugs. In addition, since cancer can be effectively targeted using ZnPP supported on the micelle, it can be usefully used for the treatment and diagnosis of cancer.
机译:本发明涉及在苯甲酰氧基肉桂醛-聚乙二醇键合的胶束上带有原卟啉锌的pH敏感性抗癌前药。本发明的在苯甲酰氧基肉桂醛-聚乙二醇键合的胶束上带有锌原卟啉的pH响应性抗癌前药通过释放ZnPP而被酸性pH分解而使癌细胞中的抗氧化剂水平降低,通过释放产生并积累(ROS)。苄氧基肉桂醛,从而促进细胞凋亡。因此,它具有通过双重刺激反应和以癌细胞特异性方式相继治疗引起的协同抗癌作用的优异效果,并且可用作抗癌药和抗癌药。另外,由于使用胶束上负载的ZnPP可以有效地靶向癌症,因此它可以有效地用于癌症的治疗和诊断。

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