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- pH pH sensitive anticancer prodrug that is 2'-benzoyloxycinnamaldehyde-polyethylene glycol micelle carrying zinc protoporphyrin and method for preparing the same
- pH pH sensitive anticancer prodrug that is 2'-benzoyloxycinnamaldehyde-polyethylene glycol micelle carrying zinc protoporphyrin and method for preparing the same
The present invention relates to a pH-sensitive anticancer prodrug drug carrying zinc protoporphyrin on a benzoyloxycinnamic aldehyde-polyethylene glycol-bonded micelle. The pH-responsive anticancer prodrug drug carrying zinc protoporphyrin on the benzoyloxycinnamaldehyde-polyethylene glycol-bonded micelle of the present invention degrades the antioxidant level in cancer cells by releasing ZnPP while being decomposed by acidic pH, (ROS) is generated and accumulated by the release of benzyloxycinnamaldehyde, thereby promoting apoptosis. Thus, it has an excellent effect of causing a synergistic anticancer effect through double stimulation reaction and sequential treatment in a cancer cell-specific manner And can be useful as anticancer drugs and anticancer drugs. In addition, since cancer can be effectively targeted using ZnPP supported on the micelle, it can be usefully used for the treatment and diagnosis of cancer.
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