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Compositon for anti-aging of cell comprising miR-186, miR-216b, miR-337-3p and miR-760

机译：包含miR-186，miR-216b，miR-337-3p和miR-760的抗衰老细胞组合物

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摘要

The present invention relates to a composition for preventing or treating cellular senescence comprising as an active ingredient a nucleic acid molecule inhibitor consisting of miR-186, miR-216b, miR-337-3p and miR-760. The miR-186, miR-216b, miR-337-3p and miR-760 inhibitors according to the present invention increase the expression of the CKII a gene in the cell, thereby reducing the production of ROS and decreasing the expression of p53 and p21 The effect of preventing or treating aging is excellent. Therefore, the present invention can be usefully used as a therapeutic agent for cell senescence.

机译：本发明涉及用于预防或治疗细胞衰老的组合物，其包含作为活性成分的由miR-186，miR-216b，miR-337-3p和miR-760组成的核酸分子抑制剂。根据本发明的miR-186，miR-216b，miR-337-3p和miR-760抑制剂可增加 CKII a 基因在细胞中的表达，从而减少ROS和降低p53和p21的表达预防或治疗衰老的效果极佳。因此，本发明可用作细胞衰老的治疗剂。 展开▼

著录项

公开/公告号KR101527749B1

专利类型

公开/公告日2015-06-12

原文格式PDF

申请/专利权人 경북대학교 산학협력단;
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申请/专利号KR20120136577

发明设计人 배영석;김수영;이영훈;
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申请日2012-11-28

分类号A61K48;A61K38/17;A61P35;

国家 KR

入库时间 2022-08-21 14:58:03

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3. COMPOSITON FOR ANTI-AGING OF CELL COMPRISING MIR-186, MIR-216B, MIR-337-3P AND MIR-760 [P] . 韩国专利： KR20140068731A . 2014-06-09

机译：包含MIR-186，MIR-216B，MIR-337-3P和MIR-760的细胞抗衰老组合物

4. Compositon for preventing or treating cancer comprising miR-186, miR-216b, miR-337-3p and miR-760 [P] . 韩国专利： KR101413581B1 . 2014-07-02

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5. COMPOSITON FOR PREVENTING OR TREATING CANCER COMPRISING MIR-186, MIR-216B, MIR-337-3P AND MIR-760 [P] . 韩国专利： KR20140060134A . 2014-05-19

机译：包含MIR-186，MIR-216B，MIR-337-3P和MIR-760的预防或治疗癌症的组合物

1. Dexmedetomidine affects the malignant biological behavior of glioma cells via miR-760/HDGF [J] . Wen-Yue Kang, Qiang Fu, Dan-Dan Xing, 海南医科大学学报(英文版) . 2020,第020期

2. Dexmedetomidine affects the malignant biological behavior of glioma cells via miR-760/HDGF [J] . Wen-Yue Kang, Qiang Fu, Dan-Dan Xing, 海南医科大学学报（英文版） . 2020,第020期

3. Upregulation of kazrin F by miR-186 suppresses apoptosis but promotes epithelial-mesenchymal transition to contribute to malignancy in human cervical cancer cells [J] . Chang Liu, Jinghua Wang, Yang Hu, 中国癌症研究（英文版） . 2017,第001期

4. Rehmannia glutinosa exhibits anti-aging effect through maintaining the quiescence and decreasing the senescence of hematopoietic stem cells [J] . Lin Bai, Gui-ying Shi, Ya-jun Yang, 动物模型与实验医学（英文） . 2018,第003期

5. Rehmannia glutinosa exhibits anti-aging effect through maintaining the quiescence and decreasing the senescence of hematopoietic stem cells [J] . Lin Bai, Gui-ying Shi, Ya-jun Yang, 动物模型与实验医学（英文） . 2018,第003期

6. MiR-186, miR-216b, miR-337-3p, and miR-760 cooperatively induce cellular senescence by targeting α subunit of protein kinase CKII in human colorectal cancer cells [J] . Biochemical and Biophysical Research Communications . 2012,第3a4期

7. MiR-186, miR-216b, miR-337-3p, and miR-760 cooperatively induce cellular senescence by targeting α subunit of protein kinase CKII in human colorectal cancer cells [J] . Biochemical and Biophysical Research Communications . 2012,第3a4期

8. Upregulation of miR-760 and miR-186 Is Associated with Replicative Senescence in Human Lung Fibroblast Cells [J] . Young-Hoon Lee, Soo Young Kim, Young-Seuk Bae Molecules and cells . 2014,第8期

9. Three-junction solar cells comprised of a thin-film GaInP/GaAs tandem cell mechanically stacked on a Si cell [C] . Yazawa Y., Tamura K., Watahiki S., IEEE International Conference on Computer Science and Automation Engineering . 2011

10. Cryopreservation effects on a pancreatic substitute comprised of beta cells or recombinant myoblasts encapsulated in nonadhesive and adhesive alginate hydrogels. [D] . Ahmad, Hajira Fatima. 2012

11. Upregulation of miR-760 and miR-186 Is Associated with Replicative Senescence in Human Lung Fibroblast Cells [O] . Young-Hoon Lee, Soo Young Kim, Young-Seuk Bae 2014

12. >MiR-216b suppresses cell proliferation, migration, invasion, and epithelialndash;mesenchymal transition by regulating FOXM1 expression in human non-small cell lung cancer [O] . Lidong Wang, Yansen Wang, Xiangyang Du, 2019

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