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Pharmaceutical composition for suppressing male fertility comprising Actin-related protein 2/3 complex inhibitor

机译:包含肌动蛋白相关蛋白2/3复合抑制剂的抑制男性生育力的药物组合物

摘要

The present invention relates to a pharmaceutical composition comprising an actin-related protein 2/3 complex inhibitor as an active ingredient for suppressing male fertility, and a contraceptive for men which comprises the same. When the actin-related protein 2/3 complex inhibitor with different concentration is applied a bovine sperm culture, sperm mobility and fertility are concentration-dependently reduced and male fertility can be reduced effectively by increasing acrosome reaction. Accordingly, since the actin-related protein 2/3 complex inhibitor of the present invention is excellent for inhibiting fertility of the sperm, it can be used as a composition for inhibiting male fertility.
机译:本发明涉及一种药物组合物,其包含肌动蛋白相关蛋白2/3复合物抑制剂作为抑制男性生育力的有效成分,以及包含该成分的男性用避孕药。当在牛精子培养物中应用不同浓度的肌动蛋白相关蛋白2/3复合抑制剂时,精子的活动性和受精能力会浓度依赖性地降低,并且通过增加顶体反应可以有效地降低雄性受精率。因此,由于本发明的肌动蛋白相关蛋白2/3复合物抑制剂对于抑制精子的生育力是优异的,因此可以用作抑制男性生育力的组合物。

著录项

  • 公开/公告号KR101501211B1

    专利类型

  • 公开/公告日2015-03-16

    原文格式PDF

  • 申请/专利权人

    申请/专利号KR20120118634

  • 发明设计人 방명걸;박유진;이준섭;

    申请日2012-10-24

  • 分类号A61K31/404;A61K31/381;A61K31/426;A61P15/16;

  • 国家 KR

  • 入库时间 2022-08-21 14:58:31

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