首页> 外国专利> Radiotracer introduced 18Ffluoromethyl group targeting neuroinflammation for PET imaging and Synthesis of Radiotracer and its biological evaluation Method for Radiotracer introduced 18Ffluoromethyl group targeting neuroinflammation for PET imaging

Radiotracer introduced 18Ffluoromethyl group targeting neuroinflammation for PET imaging and Synthesis of Radiotracer and its biological evaluation Method for Radiotracer introduced 18Ffluoromethyl group targeting neuroinflammation for PET imaging

机译：放射性示踪剂引入[18F]氟甲基靶向神经炎症用于PET显像和放射性示踪剂的合成及其生物学评价方法放射性示踪剂引入[18F]氟甲基靶向神经炎用于PET显像

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摘要

The present invention relates to an [18F]fluoromethyl group-introduced radiotracer for proton emission tomography for targeting brain neuroinflammation, a synthesis thereof, and a method for evaluating biological results using the same. In the present invention, a fluoromethyl group-introduced fluorine-18 labeled radiotracer was prepared by introducing [18F]fluoroiodomethane, in which a prosthetic group diiodomethane is labeled with fluorine-18, into PBR28-OH through two stages, or substituting fluorine-18 using a triazolium triflate precursor in one stage at high yield.

机译：本发明涉及导入[18 F]氟甲基的放射性示踪剂，其用于靶向脑神经炎症的质子发射断层摄影术，其合成以及使用其评估生物学结果的方法。在本发明中，通过将[18F]氟碘甲烷分两步引入PBR28-OH中来制备引入氟甲基的氟18标记的放射性示踪剂，其中将氟基标记的二碘甲烷取代基[18F]氟碘甲烷，或用氟-18取代。在一个阶段中以高产率使用三氟甲磺酸三唑鎓前体。

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公开/公告号KR20150030934A

专利类型
公开/公告日2015-03-23

原文格式PDF
申请/专利权人 BIO IMAGING KOREA CO. LTD.;
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申请/专利号KR20130110282
发明设计人 LEE BYUNG CHUL;MOON BYUNG SEOK;JUNG JAE HO;
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申请日2013-09-13
分类号A61K51/04;A61K51/02;A61P29;
国家 KR
入库时间 2022-08-21 15:00:31

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