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RESTORING PHOSPHORYLATION OF A NOVEL PINK1 SUBSTRATE TO TREAT PARKINSON'S DISEASE

机译:恢复新型PINK1基质的磷酸化以治疗帕金森氏病

摘要

The present application relates to the field of Parkinson's disease (PD), particularly sporadic PD or PD associated with mutations in the mitochondrial kinase PINK1. A new substrate for this kinase, NdufA10, is identified herein. In Parkinson's disease, this protein is dephosphorylated, which is linked to a loss of mitochondrial membrane potential. It is shown that restoring or mimicking phosphorylation of NdufA10 restores the phenotypic defects associated with Parkinson's disease and is thus a new therapeutic paradigm.
机译:本申请涉及帕金森氏病(PD)领域,特别是散发的PD或与线粒体激酶PINK1中的突变相关的PD。本文鉴定了该激酶的新底物NdufA10。在帕金森氏病中,该蛋白质被去磷酸化,这与线粒体膜电位的丧失有关。结果表明,恢复或模拟NdufA10的磷酸化可恢复与帕金森氏病相关的表型缺陷,因此是一种新的治疗范例。

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