首页> 外国专利> COMBINATION OF CD37 ANTIBODIES WITH ICE (IFOSFAMIDE, CARBOPLATIN, ETOPOSIDE)

COMBINATION OF CD37 ANTIBODIES WITH ICE (IFOSFAMIDE, CARBOPLATIN, ETOPOSIDE)

机译:CD37抗体与冰的组合(异环磷酰胺,卡铂,乙交酯)

摘要

The present invention relates to immunotherapies that are based on depletion of CD37-positive cells such as B-cells. The present invention provides methods for reduction of CD37-positive cells such as B-cells in an individual/patient using a combination of CD37 antibody/antibodies and ICE. The combination of CD37 antibodies and ICE is shown to have improved anti-tumor efficacy compared to single agent treatment. The application further provides materials and methods for treatment of diseases involving aberrant B-cell activity.
机译:本发明涉及基于CD37阳性细胞如B细胞的消耗的免疫疗法。本发明提供了使用CD37抗体/抗体和ICE的组合在个体/患者中减少CD37阳性细胞如B细胞的方法。与单药治疗相比,CD37抗体和ICE的组合具有更高的抗肿瘤功效。本申请进一步提供了用于治疗涉及异常B细胞活性的疾病的材料和方法。

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