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COMBINATION OF CD37 ANTIBODIES WITH ICE (IFOSFAMIDE, CARBOPLATIN, ETOPOSIDE)
COMBINATION OF CD37 ANTIBODIES WITH ICE (IFOSFAMIDE, CARBOPLATIN, ETOPOSIDE)
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机译:CD37抗体与冰的组合(异环磷酰胺,卡铂,乙交酯)
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摘要
The present invention relates to immunotherapies that are based on depletion of CD37-positive cells such as B-cells. The present invention provides methods for reduction of CD37-positive cells such as B-cells in an individual/patient using a combination of CD37 antibody/antibodies and ICE. The combination of CD37 antibodies and ICE is shown to have improved anti-tumor efficacy compared to single agent treatment. The application further provides materials and methods for treatment of diseases involving aberrant B-cell activity.
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