A method of treating diffuse large B cell lymphoma in a mammal comprising the step of: administering a pharmaceutical acceptable amount of a combination of anti-cancer drugs to a patient wherein the combination includes a first compound and a second compound; the first compound being selected from the group consisting of an mTOR inhibitor, a BTK inhibitor, an HDAC inhibitor, an anti-CD20 monoclonal antibody, a hypomethylating agent and an immunomodulant, and the second compound being a thienotriazolodiazepine compound being represented by the following Formula (1): wherein R1 is alkyl having a carbon number of 1-4, R2 is a hydrogen atom; a halogen atom; or alkyl having a carbon number of 1 -4 optionally substituted by a halogen atom or a hydroxyl group, R3 is a halogen atom; phenyl optionally substituted by a halogen atom, alkyl having a carbon number of 1-4, alkoxy having a carbon number of 1-4 or cyano;— NR5— (CH2)m— R6 wherein R5 is a hydrogen atom or alkyl having a carbon number of 1-4, m is an integer of 0-4, and R6 is phenyl or pyridyl optionally substituted by a halogen atom; or -NR7— CO— (CH2)n— R8 wherein R7 is a hydrogen atom or alkyl having a carbon number of 1-4, n is an integer of 0-2, and R8 is phenyl or pyridyl optionally substituted by a halogen atom, and R4 is— (CH2)a— CO— NH— R9 wherein a is an integer of 1-4, and R9 is alkyl having a carbon number of 1 -4; hydroxyalkyl having a carbon number of 1-4; alkoxy having a carbon number of 1 -4; or phenyl or pyridyl optionally substituted by alkyl having a carbon number of 1-4, alkoxy having a carbon number of 1 -4, amino or a hydroxyl group or— (CH2)b— COOR10 wherein b is an integer of 1 -4, and R10 is alkyl having a carbon number of 1-4, or a pharmaceutically acceptable salt thereof or a hydrate or solvate thereof.
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机译：一种在哺乳动物中治疗弥漫性大B细胞淋巴瘤的方法，其包括以下步骤：向患者施用药学可接受量的抗癌药物组合，其中所述组合包含第一化合物和第二化合物;第一种化合物选自mTOR抑制剂，BTK抑制剂，HDAC抑制剂，抗CD20单克隆抗体，次甲基化剂和免疫调节剂，第二种化合物为噻吩并三氮杂二氮杂compound化合物，由下式表示（1）：其中R 1 是碳数为1-4的烷基，R 2 是氢原子;卤素原子; R 3 为碳原子数为1 -4的烷基，可任选被卤原子或羟基取代。任选被卤素原子取代的苯基，碳原子数为1-4的烷基，碳原子数为1-4的烷氧基或氰基;-NR 5 -（CH 2 ） m -R 6 其中R 5 是氢原子或碳原子数为1-4的烷基，m是整数0-4，且R 6 为苯基或吡啶基，任选地被卤素原子取代;或-NR 7 -CO-（CH 2 ） n -R 8 其中R 7 < / Sup>为氢原子或碳原子数为1-4的烷基，n为0-2的整数，R 8 为苯基或吡啶基，可选地被卤素原子取代，R 4 是-（CH 2 ） a -CO- NH- R 9 其中a是1的整数-4，且R 9 是碳数为1-4的烷基;碳数为1-4的羟烷基;碳数为1-4的烷氧基;或任选地被碳原子数为1-4的烷基，碳原子数为1-4的烷氧基，氨基或羟基或-（CH 2 ） b < / Sub>-COOR 10 ，其中b是1-4的整数，R 10 是碳数为1-4的烷基，或其药学上可接受的盐或其水合物或溶剂化物。
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