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PHOTOCHEMICAL PROCESS FOR THE FLUORTNATION OF AN ORGANIC COMPOUND HAVING AN UNACTIVATED SP3 C-H BOND

机译:SP 3 C-H键未活化的有机化合物的光化学过程

摘要

The application provides a photochemical process for the chemoselective fluorination of an organic compound by combining a carbon-containing compound having an unactivated sp3 C-H bond with a reagent system comprised of a fluorinating agent, and a photocatalyst, in the presence of a light source. Provided as fluorinating agent is N-fluorobenzenesulfonimide (NFSI) or 1-chloromethy1-4-fluoro-1,4-diazoniabicyclo[2.2.2]octane bis(tetrafluoroborate) (Selectfluor™), as photocatalyst is tetrabutylammonium decatungstate (TBADT), and as light source is a 365 nm UV lamp. The reactions conditions result in the C-H bond being replaced by a C-F bond, to provide a fluorinated carbon-containing compound.
机译:本申请通过将具有未活化的sp 3 CH键的含碳化合物与由氟化剂和光催化剂组成的试剂体系结合,提供了一种有机化合物的化学选择性氟化的光化学方法。光源的存在。作为氟化剂,提供N-氟苯磺酰亚胺(NFSI)或1-氯甲基1-4-氟-1,4-二氮杂双环[2.2.2]辛烷双(四氟硼酸酯)(Selectfluor™),因为光催化剂是四丁基癸二酸铵(TBADT),并且作为光源的是365 nm紫外线灯。反应条件导致C-H键被C-F键取代,从而提供氟化的含碳化合物。

著录项

  • 公开/公告号WO2015000076A1

    专利类型

  • 公开/公告日2015-01-08

    原文格式PDF

  • 申请/专利权人 ALECTOS THERAPEUTICS INC.;

    申请/专利号WO2014CA50629

  • 发明设计人 HALPERIN SHIRA;BRITTON ROBERT J.;

    申请日2014-07-02

  • 分类号C07B39/00;

  • 国家 WO

  • 入库时间 2022-08-21 15:09:09

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