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COMPOSITIONS AND METHODS RELATED TO RECOMBINANT ANTIBODIES TO HISTONE POSTTRANSLATIONAL MODIFICATIONS

机译:与组蛋白翻译后修饰的重组抗体有关的组合物和方法

摘要

Embodiments concern compositions and methods involving recombinant antibodies to histone post-translational modifications. The invention provides compositions and methods for histone methyltransferase assays. In certain embodiments, the compositions and methods involve a recombinant antibody that binds histone H3 fragment harboring biomarkers such as H3K9me3 mark, H3K4me3 mark, H3K36me3 mark, H3K27me3, H3K9me3 and H3S10phos or a recombinant antibody that binds histone H4 fragment harboring H4K20me3 mark.
机译:实施方案涉及涉及针对组蛋白翻译后修饰的重组抗体的组合物和方法。本发明提供了用于组蛋白甲基转移酶测定的组合物和方法。在某些实施方案中,所述组合物和方法包括结合具有生物标记物如H3K9me3标记,H3K4me3标记,H3K36me3标记,H3K27me3,H3K9me3和H3S10phos的组蛋白H3片段的重组抗体或结合具有H4K20me3标记的组蛋白H4片段的重组抗体。

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