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G-RICH ISODNA SEQUENCES FORMING G-QUADRUPLEX STRUCTURE, THEIR FUNCTION AS APTAMERS AND A PROCESS FOR THE PREPARATION THEREOF
G-RICH ISODNA SEQUENCES FORMING G-QUADRUPLEX STRUCTURE, THEIR FUNCTION AS APTAMERS AND A PROCESS FOR THE PREPARATION THEREOF
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机译:富含G的ISODNA序列,形成G-四链结构,它们作为适体的功能及其制备方法
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摘要
The present invention relates to G-quadruplex forming isoDNA aptamers and a process for the preparation thereof. The present invention further relates to a stable, non-genetic, guanine rich 2'- 5' linked isoDNA selected from 3' deoxy 2'-5' isoDNA and 3' deoxy 2' -5' isoDNA-isoRNA hybrid. The instant 2'-5' linked isoDNA such as the thrombin binding aptamer (isoTBA) can be used in deep vein thrombosis, where prolonged anticoagulant activity is required.
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