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USE OF ABC DRUG EFFLUX INHIBITORS IN COMBINATION WITH ANTI-NEURODEGENERATIVE DRUGS IN THE TREATMENT OF NEURODEGENERATIVE DISORDERS

机译：ABC药物外流抑制剂与抗神经退行性药物的组合在治疗神经退行性疾病中的应用

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摘要

The present invention provides a method of treating or ameliorating a neurodegenerative disease in a mammal, the method comprising administering to the mammal a therapeutically effective amount of a neurodegenerative disease drug, wherein the drug is a substrate of an ABC transporter inhibitor, wherein the mammal is further administered a therapeutically effective amount of an ABC transporter inhibitor, whereby the neurodegenerative disease is treated in the mammal. In certain embodiments, the neurodegenerative disease comprises at least one selected from the group consisting of spinal cord injury, Alzheimer' s disease, Parkinson's disease, Huntington's disease, prion disease, amyotrophic lateral sclerosis, a tauopathy, and chronic traumatic encephalopathy.

机译：本发明提供了一种在哺乳动物中治疗或改善神经退行性疾病的方法，该方法包括向哺乳动物施用治疗有效量的神经退行性疾病药物，其中该药物是ABC转运蛋白抑制剂的底物，其中哺乳动物是进一步施用治疗有效量的ABC转运蛋白抑制剂，从而在哺乳动物中治疗神经退行性疾病。在某些实施方案中，神经变性疾病包括选自以下的至少一种：脊髓损伤，阿尔茨海默氏病，帕金森氏病，亨廷顿氏病，病毒病，肌萎缩性侧索硬化，牛磺酸病和慢性创伤性脑病。

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公开/公告号CA2933464A1

专利类型
公开/公告日2015-06-18

原文格式PDF
申请/专利权人 THOMAS JEFFERSON UNIVERSITY;
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申请/专利号CA20142933464
发明设计人 TROTTI DAVIDE;PASINELLI PIERA;JABLONSKI MICHAEL R.;
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申请日2014-12-09
分类号A61K31/473;A61K31/05;A61K31/122;A61K31/19;A61K31/197;A61K31/198;A61K31/355;A61K31/417;A61K31/428;A61K31/454;A61K31/4725;A61K31/496;A61K31/522;A61K31/546;A61K31/55;A61K31/635;A61K31/65;A61K31/7048;A61K31/714;A61K38/18;A61K38/30;A61K38/55;A61P25/28;
国家 CA
入库时间 2022-08-21 15:11:05

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