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POLYMORPHISMS IN THE HUMAN CYP2D6 GENE PROMOTER REGION AND THEIR USE IN DIAGNOSTIC AND THERAPEUTIC APPLICATIONS
POLYMORPHISMS IN THE HUMAN CYP2D6 GENE PROMOTER REGION AND THEIR USE IN DIAGNOSTIC AND THERAPEUTIC APPLICATIONS
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机译:CYP2D6基因启动子区的多态性及其在诊断和治疗应用中的用途
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摘要
Provided are polynucleotides of molecular variant promoters of the CYP2D6 genewhich, for example, are associated with abnormal drug response or individualpredisposition to several common diseases and disorders caused by drug under-or over-metabolization, and vectors comprising such polynucleotides.Furthermore, methods of diagnosing the status of disorders related tointermediate metabolization of drugs are described. In addition, kitscomprising oligonucleotides hybridizing to the CYP2D6 promoter and/or beingcapable of being extended into this region useful for diagnosing subjects thatare ultrarapid or intermediate metabolizer of drugs are provided.
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