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Methods and compositions for the inhibition of innate immune responses and autoimmunity

机译:抑制先天免疫应答和自身免疫的方法和组合物

摘要

An oligonucleotide for use in inhibiting a TLR9-dependent and TLR7 / 8-dependent immune response in an individual, wherein the oligonucleotide has less than about 200 bases or base pairs and the oligonucleotide comprises an immunoregulatory nucleic acid sequence, in that the immunoregulatory nucleic acid sequence comprises (a) at least one TGC trinucleotide sequence at the 5 'end of the oligonucleotide and (b) a nucleotide sequence of the formula: X1GGGGX2X3, wherein X1, X2 and X3 are nucleotides, with the condition that if X1 = C or A, then X2X3 is not AA.
机译:一种用于抑制个体中TLR9依赖性和TLR7 / 8依赖性免疫应答的寡核苷酸,其中该寡核苷酸具有少于约200个碱基或碱基对,并且该寡核苷酸包含免疫调节核酸序列,因为该免疫调节核酸该序列包含(a)在寡核苷酸的5'末端的至少一个TGC三核苷酸序列和(b)下式的核苷酸序列:X1GGGGX2X3,其中X1,X2和X3是核苷酸,条件是如果X1> = C或A,则X2X3不是AA。

著录项

  • 公开/公告号ES2543207T3

    专利类型

  • 公开/公告日2015-08-17

    原文格式PDF

  • 申请/专利权人 DYNAVAX TECHNOLOGIES CORPORATION;

    申请/专利号ES20100011096T

  • 发明设计人 BARRAT FRANCK;COFFMAN ROBERT L.;

    申请日2005-08-24

  • 分类号C12N15/117;A61K31/7115;

  • 国家 ES

  • 入库时间 2022-08-21 15:11:54

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