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Methods and compositions for the inhibition of innate immune responses and autoimmunity
Methods and compositions for the inhibition of innate immune responses and autoimmunity
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机译:抑制先天免疫应答和自身免疫的方法和组合物
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摘要
An oligonucleotide for use in inhibiting a TLR9-dependent and TLR7 / 8-dependent immune response in an individual, wherein the oligonucleotide has less than about 200 bases or base pairs and the oligonucleotide comprises an immunoregulatory nucleic acid sequence, in that the immunoregulatory nucleic acid sequence comprises (a) at least one TGC trinucleotide sequence at the 5 'end of the oligonucleotide and (b) a nucleotide sequence of the formula: X1GGGGX2X3, wherein X1, X2 and X3 are nucleotides, with the condition that if X1 = C or A, then X2X3 is not AA.
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