• 主题
高级搜索  >
历史搜索 清空历史
首页> 外国专利> Biocompatible polymer nanocapsules with quantum dots, method of manufacturing them and their application

Biocompatible polymer nanocapsules with quantum dots, method of manufacturing them and their application

机译：具有量子点的生物相容性聚合物纳米胶囊，其制备方法及其应用

页面导航
  • 摘要
  • 著录项
  • 相似文献

摘要

The invention reveals biocompatible quantum dot nanocapsules whose outer coating is a non-ionic surfactant in the form of polyethoxylated castor oil, between the outer shell and the oil core loaded with quantum dots constituting the CdSe-ZnS markers of the "core-shell" type, there is a layer of triblocal polymer consisting of 20-units polyoxyethylene (PEO),followed by 70-units of polyoxypropylene (PPO),and then 20-units of polyoxyethylene (PEO) again. The invention also concerns the production of biocompatible quantum dot nanocapsules, which consists of the dissolution in the first stage of 4.6 ml dichloromethane of 150 g triblocal polymer consisting of 20 units of polyoxyethylene (PEO),followed by 70-units of polyoxypropylene (PPO),and then 20-units of polyoxyethylene (PEO) again,12.5-50 mg of oil and 1-3 mg of CdSe-ZnS "core-coating" quantum droplets dissolved in hexane, Then the prepared organic phase is mixed for thirty minutes at temperature 25,C. In the second stage the whole is subjected to ultrasound for 90 seconds and the excess solvent evaporates under reduced pressure at temperature 40,C and in the third stage 5,ml of water, which is a solution of polyethoxylated castor oil, 50 mg/ml in the evaporated mixture,the whole is mixed at temperature 40oC for two hours and the resulting suspension of polymer nanocapsules loaded with quantum dots CdSe/ZnS is subjected to ultrasound for three-8 minutes and mixed for another 12-hour period at room temperature, then, in the third stage, the loaded polymer nano-capsules are subjected to a process of nanofiltration by polyether sulfone membranes of a diameter of 200 nm. The result also includes the use of biocompatible nanocapsules with quantum dots with an outer coating,which is a non-ionic surfactant in the form of polyethoxylated castor oil, with a layer of triblocal polymer consisting of 20-polyoxyethylene (PEO) units between the outer shell and the oil core loaded with quantum dots constituting the CdSe-ZnS markers of the "core-shell" type,followed by 70-units of polyoxypropylene (PPO),and then again 20-units of polyoxyethylene (PEO) as biocompatible fluorescent markers in cancer therapy.
机译：本发明揭示了生物相容性量子点纳米胶囊，其外部涂层是聚乙氧基化蓖麻油形式的非离子表面活性剂，位于外壳和油核之间，该油核装有构成“核-壳”型CdSe-ZnS标记的量子点，有一层由20个单元的聚氧乙烯（PEO）组成，接着是70个单元的聚氧丙烯（PPO），然后又是20个单元的聚氧乙烯（PEO）组成的triblocal聚合物层。本发明还涉及生物相容性量子点纳米胶囊的生产，其包括在第一阶段中溶解由20个单元的聚氧乙烯（PEO）组成的150g的三聚体聚合物在4.6ml的二氯甲烷中的溶解，随后是70个单位的聚氧丙烯（PPO）。然后再将20单位的聚氧乙烯（PEO），12.5-50 mg的油和1-3 mg的CdSe-ZnS“核心包被”量子液滴溶解在己烷中，然后将制备的有机相在室温下混合30分钟温度25，C。在第二阶段中，对整体进行超声处理90秒，然后在减压下于40°C的温度蒸发掉多余的溶剂，在第三阶段中，将5ml水（50mg / ml的聚乙氧基化蓖麻油溶液）蒸发掉。在蒸发的混合物中，将整体在40°C的温度下混合2小时，然后将所得的载有量子点CdSe / ZnS的聚合物纳米胶囊的悬浮液超声处理3-8分钟，并在室温下再混合12小时，然后，在第三阶段中，将负载的聚合物纳米胶囊通过直径为200 nm的聚醚砜膜进行纳米过滤。结果还包括使用具有量子点且具有外部涂层的生物相容性纳米胶囊，该外部涂层是聚乙氧基化蓖麻油形式的非离子表面活性剂，在外部之间有一层由20-聚氧乙烯（PEO）单元组成的摩擦局部聚合物层壳和油核上装有构成“核-壳”型CdSe-ZnS标记的量子点，然后是70单位的聚氧丙烯（PPO），然后再是20单位的聚氧乙烯（PEO）作为生物相容性荧光标记在癌症治疗中。

著录项

相似文献

  • 专利
  • 外文文献
  • 中文文献
获取专利

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号