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ALK1 ANTAGONISTS AND THEIR USES IN TREATING RENAL CELL CARCINOMA.
ALK1 ANTAGONISTS AND THEIR USES IN TREATING RENAL CELL CARCINOMA.
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机译：ALK1拮抗剂及其在治疗肾细胞癌中的用途。
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摘要
In certain aspects, the present disclosure relates to the insight that a polypeptide comprising a ligand-binding portion of the extracellular domain of activin-like kinase I (ALK1) polypeptide may be used to inhibit tumor growth of renal cell carcinoma (RCC) in vivo. In additional aspects the disclosure relates to the insight that a polypeptide comprising a ligand-binding portion of the extracellular domain of ALK1 dramatically increases the ability of a standard of care receptor tyrosine kinase inhibitor to inhibit RCC tumor growth in vivo.
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