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METHODS FOR PREPARING HUMAN MELANOCYTES FROM HUMAN PLURIPOTENT STEM CELLS

机译:从人多能干细胞制备人黑素细胞的方法

摘要

The invention relates to an ex vivo method for obtaining a population of human melanocytes derived from human pluripotent stem cells comprising the step consisting of co-culturing human pluripotent stem cells with cells that support ectodermal differentiation in the presence of an agent that stimulates epidermal induction and an agent that stimulates terminal differentiation of keratinocytes. The invention also relates to human melanocytes obtainable by said method and to uses thereof in cell therapy and in screening assays.
机译:本发明涉及一种用于获得源自人多能干细胞的人黑素细胞群的离体方法,该方法包括以下步骤:在刺激表皮诱导和脱氢的试剂存在下,将人多能干细胞与支持外胚层分化的细胞共同培养。刺激角质形成细胞终末分化的药物。本发明还涉及可通过所述方法获得的人黑素细胞及其在细胞治疗和筛选测定中的用途。

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