首页> 外国专利> Pyrimidine substituted pyridines Compounds, inhibitors of serine / Threonine Kinases; Preparation procedure; Compound Pharmaceutical composition; Pharmaceutical Intermediates; Combination; use for Treatment of a disease such as cancer, melanoma hiperproliferativa, leuce Mine and an inflammatory disease such as Arthritis and rheumatism, among others.

Pyrimidine substituted pyridines Compounds, inhibitors of serine / Threonine Kinases; Preparation procedure; Compound Pharmaceutical composition; Pharmaceutical Intermediates; Combination; use for Treatment of a disease such as cancer, melanoma hiperproliferativa, leuce Mine and an inflammatory disease such as Arthritis and rheumatism, among others.

机译：嘧啶取代的吡啶化合物，丝氨酸/苏氨酸激酶的抑制剂;准备程序;复合药物组合物;医药中间体组合;用于治疗疾病，例如癌症，黑色素瘤，增殖性红血球，白粉病和炎性疾病，例如关节炎和风湿病等。

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摘要

Compounds of Formula I or a stereoisomer, tautomer, prodrug or pharmaceutically acceptable salt thereof are provided, which are useful for the treatment of hyperproliferative, pain and inflammatory diseases. Methods of using compounds of Formula I or a stereoisomer, tautomer, prodrug or pharmaceutically acceptable salt thereof, for in vitro , in situ , and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions are disclosed.

机译：提供了式I化合物或其立体异构体，互变异构体，前药或其药学上可接受的盐，其可用于治疗过度增殖，疼痛和炎性疾病。公开了使用式I化合物或其立体异构体，互变异构体，前药或药学上可接受的盐，用于在体外，原位和体内诊断，预防或治疗哺乳动物细胞中此类疾病或相关病理状况的方法。

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公开/公告号CL2014002301A1

专利类型
公开/公告日2015-05-08

原文格式PDF
申请/专利权人 GENENTECH INC.;ARRAY BIOPHARMA INC.;
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申请/专利号CL20140002301
发明设计人 CHEN HUIFEN;BLAKE JAMES F.;CHICARELLI MARK JOSEPH;GARREY RUSTAM FERDINAND;GAUDINO JOHN;GRINA JONAS;MORENO DAVID A.;MOHR PETER J.;REB LI;SCHWARZ JACOB;ROBARGE KIRK;ZHOU AIHE;
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申请日2014-08-29
分类号A61K31/435;A61K31/506;A61P29;A61P35;C07D401/04;C07D401/14;C07D405/14;C07D409/14;C07D413/14;C07D417/14;
国家 CL
入库时间 2022-08-21 15:15:54

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