首页> 外国专利> 'In vitro or in vivo method of compound selection, use and cosmetic use of a human isovaleryl coenzyme dehydrogenase (ivd) enzyme modulator, in vitro diagnostic or monitoring methods and determination of an individual's susceptibility to acne development' and uses of an ivd gene or protein '

'In vitro or in vivo method of compound selection, use and cosmetic use of a human isovaleryl coenzyme dehydrogenase (ivd) enzyme modulator, in vitro diagnostic or monitoring methods and determination of an individual's susceptibility to acne development' and uses of an ivd gene or protein '

机译：“化合物的体外选择或体内选择，人类异戊酰基辅酶脱氢酶（ivd）酶调节剂的使用和美容用途，体外诊断或监测方法以及确定个体对痤疮发展的敏感性”和ivd基因或蛋白质

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摘要

An in vitro or in vivo method for screening for candidate compounds for the preventive or curative treatment of acne, of seborrhoeic dermatitis or of skin disorders associated with hyperseborrhoea, includes determining the ability of a compound to modulate the expression or the activity of isovaleryl-coenzyme A dehydrogenase (IVD), and also utilizes modulators of the expression or of the activity of this enzyme, for the treatment of acne, of seborrhoeic dermatitis or of skin disorders associated with hyperseborrhoea; methods for the in vitro diagnosis of or in vitro prognosis for these pathologies are also featured.

机译：筛选用于预防或治疗痤疮，脂溢性皮炎或与脂溢性皮炎相关的皮肤疾病的候选化合物的体外或体内方法，包括确定化合物调节异戊酰辅酶的表达或活性的能力。脱氢酶（IVD），并且还利用该酶的表达或活性调节剂来治疗痤疮，脂溢性皮炎或与脂溢性皮炎相关的皮肤疾病;还介绍了这些病理的体外诊断或体外预后的方法。

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公开/公告号BRPI0908313A2

专利类型
公开/公告日2015-08-18

原文格式PDF
申请/专利权人 GALDERMA RESEARCH & DEVELOPMENT;
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申请/专利号BR2009PI08313
发明设计人 JÉRÔME AUBERT;MICHEL RIVIER;TONY MINIER;VALÉRIE TRINQUET;
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申请日2009-05-07
分类号G01N33/68;C12Q1/68;
国家 BR
入库时间 2022-08-21 15:15:58

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