首页> 外国专利> Compound or salt or hydrate thereof, pharmaceutical composition, methods for modulating p2x7 receptor activity, for treating a condition responsive to p2x7 receptor modulation in a patient, for inhibiting retinal ganglionic cell death in a patient for determination the presence or absence of a p2x7 receptor in a sample, packaged pharmaceutical preparation, and use of a compound or salt or hydrate thereof.

Compound or salt or hydrate thereof, pharmaceutical composition, methods for modulating p2x7 receptor activity, for treating a condition responsive to p2x7 receptor modulation in a patient, for inhibiting retinal ganglionic cell death in a patient for determination the presence or absence of a p2x7 receptor in a sample, packaged pharmaceutical preparation, and use of a compound or salt or hydrate thereof.

机译：化合物或其盐或水合物，药物组合物，调节p2x7受体活性的方法，用于治疗患者中响应p2x7受体调节的病症，用于抑制患者视网膜神经节细胞死亡的方法，以确定是否存在p2x7受体。样品，包装的药物制剂以及化合物或其盐或水合物的用途。

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摘要

Compounds, pharmaceutical compositions, and methods of use are disclosed for heteroaryl amide analogues of formula Ia and/or Ib: . In certain embodiments, the heteroaryl amide analogues are agonists and/or ligands of dopamine receptors and may be useful, inter alia, for the treatment of a condition responsive to P2X7 receptor modulation, for example, pain, inflammation, a neurological or neurodegenerative disorder, a cardiovascular disorder, an ocular disorder or an immune system disorder.

机译：公开了式Ia和/或Ib的杂芳基酰胺类似物的化合物，药物组合物和使用方法。在某些实施方案中，杂芳基酰胺类似物是多巴胺受体的激动剂和/或配体，并且尤其可用于治疗对P2X7受体调节有响应的病症，例如疼痛，炎症，神经或神经退行性疾病，心血管疾病，眼部疾病或免疫系统疾病。

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公开/公告号BRPI0812594A2

专利类型
公开/公告日2015-06-23

原文格式PDF
申请/专利权人 H. LUNDBECK A/S;
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申请/专利号BR2008PI12594
发明设计人 RAJAGOPAL BAKTHAVATCHALAM;DAVID C. IHLE;SCOTT M. CAPITOSTI;DAVID J. WUSTROW;JUN YUAN;
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申请日2008-08-11
分类号C07D487/04;
国家 BR
入库时间 2022-08-21 15:16:10

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