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biphenyloxy alkyl amines and aryloxy alkyl amines derivatives, pharmaceutical composition, use of the pharmaceutical composition in the treatment or prevention or inhibition of chronic pulmonary inflammatory diseases and method of treatment or prevention of such diseases

机译：联苯氧基烷基胺和芳氧基烷基胺衍生物，药物组合物，该药物组合物在治疗或预防或抑制慢性肺炎性疾病中的用途以及此类疾病的治疗或预防方法

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摘要

biphenyloxy alkyl amines and aryloxy alkyl amines derivatives, pharmaceutical composition, use of the pharmaceutical composition in the treatment or prevention or inhibition of chronic pulmonary inflammatory diseases and method of treatment or prevention of such diseases. The present invention relates to biphenyloxyalkylamines and aryloxyalkylamines derivatives, structurally analogous to mexiletine, with important biological activities and devoid of undesirable side effects present in the prototype, as well as in other drugs of the same therapeutic class. prototype. The derivatives of the present invention have formulas II and III and are used in the treatment or prevention or inhibition of inflammatory pulmonary diseases, such as asthma and chronic obstructive pulmonary disease (dpoc).

机译：联苯氧基烷基胺和芳氧基烷基胺衍生物，药物组合物，药物组合物在治疗或预防或抑制慢性肺炎性疾病中的用途以及此类疾病的治疗或预防方法。本发明涉及在结构上类似于美西律的联苯氧基烷基胺和芳氧基烷基胺衍生物，其具有重要的生物学活性并且在原型以及在相同治疗类别的其他药物中没有不良副作用。原型。本发明的衍生物具有式II和III，并且用于治疗或预防或抑制炎症性肺病，例如哮喘和慢性阻塞性肺病（dpoc）。

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公开/公告号BR102013020313A2

专利类型
公开/公告日2015-10-06

原文格式PDF
申请/专利权人 FUNDAÇÃO OSWALDO CRUZ (FIOCRUZ);
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申请/专利号BR20131020313
发明设计人 EMERSON TEIXEIRA DA SILVA;JORGE CARLOS SANTOS DA COSTA;MAGDA FRAGUAS SERRA;MARCO AURÉLIO MARTINS;MARCUS VINICIUS NORA DE SOUZA;ROBSON XAVIER FARIA;
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申请日2013-08-09
分类号C07C217/14;A61K31/138;A61P11/06;
国家 BR
入库时间 2022-08-21 15:16:21

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