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Transmucosal drug delivery device and method including electrically-actuated permeation enhancement

机译:包括电促渗透增强的透粘膜药物递送装置和方法

摘要

Intralumenal devices and methods are provided for transmucosal drug delivery. The device may comprise a housing configured for intralumenal deployment into a human or animal subject; a drug-dispensing portion which contains at least one drug; and an electrically-actuatable portion configured to disrupt at least one region of a mucosal barrier adjacent to the housing at a selected time while intralumenally deployed in the human or animal subject. The device may be operable to dispense the drug from the housing to a region of the mucosal barrier disrupted by the electrically-actuatable portion.
机译:提供用于透粘膜药物递送的内部装置和方法。该装置可以包括配置成用于腔内部署到人类或动物受试者中的外壳;包含至少一种药物的药物分配部分;以及可电致动部分,其配置成在选定的时间在将腔内部署在人或动物受试者中时破坏与壳体相邻的粘膜屏障的至少一个区域。该装置可用于将药物从壳体分配到粘膜屏障的被电可致动部分破坏的区域。

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