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Chemical switches for detecting reactive chemical agents

机译:用于检测化学反应剂的化学开关

摘要

Certain embodiments of the present invention relate to the preparation of microbeads that exhibit a “turn on” fluorescence response within seconds of exposure to an analyte vapor (e.g., a chemical warfare agent or a reactive stimulant). This sensing approach is modeled after the mechanism for inhibition of acetylcholinesterase enzyme activity, and utilizes a specific and irreversible reaction between phosphonyl halides and a fluorescent indicator. The present invention also relates to a sensor and a method for sensing an analyte through detection of changes in the fluorescing properties of the inventive microbeads.
机译:本发明的某些实施方案涉及微珠的制备,所述微珠在暴露于分析物蒸气(例如化学战剂或反应性刺激剂)的几秒钟内显示出“开启”荧光响应。该感测方法以抑制乙酰胆碱酯酶活性的机制为模型,并利用膦酰卤化物和荧光指示剂之间的特异性且不可逆的反应。本发明还涉及用于通过检测本发明的微珠的荧光性质的变化来感测分析物的传感器和方法。

著录项

  • 公开/公告号US8932869B2

    专利类型

  • 公开/公告日2015-01-13

    原文格式PDF

  • 申请/专利权人 DAVID R. WALT;SANDRA BENCIC-NAGALE;

    申请/专利号US20070279899

  • 发明设计人 DAVID R. WALT;SANDRA BENCIC-NAGALE;

    申请日2007-02-22

  • 分类号G01N21/64;C07D311/82;G01N33/00;C07D219/06;

  • 国家 US

  • 入库时间 2022-08-21 15:19:34

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