首页> 外国专利> USE OF miR-23a-3p AND/OR miR-27a-3p MIMICS AS THERAPEUTIC AGENTS FOR INHIBITION OF NEURONAL APOPTOSIS FOLLOWING BRAIN INJURY

USE OF miR-23a-3p AND/OR miR-27a-3p MIMICS AS THERAPEUTIC AGENTS FOR INHIBITION OF NEURONAL APOPTOSIS FOLLOWING BRAIN INJURY

机译:使用miR-23a-3p和/或miR-27a-3p Mimics作为治疗性脑损伤后神经胶质细胞凋亡的抑制剂

摘要

The present invention relates to a method for treating a brain injury due to a traumatic event, disease or ischemic attack in a mammal subject, wherein the method comprises administering to the mammal subject an effective amount of miR-23a-3p and/or miR-27a-3p mimics to reduce activation of Puma, Noxa and Bax therby causing a subsequent reduction in neuronal apoptosis.
机译:本发明涉及一种在哺乳动物受试者中治疗由于外伤事件,疾病或局部缺血发作所致的脑损伤的方法,其中该方法包括向哺乳动物受试者施用有效量的miR-23a-3p和/或miR- 27a-3p模拟物可减少Puma,Noxa和Bax ther的激活,从而引起神经元凋亡的减少。

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