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IDH1-Mutated Human Glioblastoma Cell Lines and Xenografts

机译：IDH1突变的人类胶质母细胞瘤细胞系和异种移植物

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摘要

IDH1-mutant cell lines and xenografts (e.g., IDH1R132H heterozygous and IDH1R132H homozygous) are derived from human glioblastoma multiforme (GBM) samples. Methods use said cells and xenografts as tools for determining the impact of IDH1R132H on cancer properties including cellular morphology, tumorigenesis, DNA, apoptosis, and metabolic profiles. Methods also use these cell lines for the screening and identification of candidate therapeutic targets.

机译：IDH1突变细胞系和异种移植物（例如IDH1R132H杂合子和IDH1R132H纯合子）衍生自人成胶质细胞瘤（GBM）样品。方法使用所述细胞和异种移植物作为确定IDH1R132H对癌症特性（包括细胞形态，肿瘤发生，DNA，细胞凋亡和代谢谱）的影响的工具。方法还使用这些细胞系来筛选和鉴定候选治疗靶标。

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公开/公告号US2014356291A1

专利类型
公开/公告日2014-12-04

原文格式PDF
申请/专利权人 DUKE UNIVERSITY;
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申请/专利号US201214364029
发明设计人 DARELL D. BIGNER;HAI YAN;
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申请日2012-12-10
分类号C12N5/079;C12Q1/02;A61K49/00;C12Q1/68;
国家 US
入库时间 2022-08-21 15:21:15

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