首页> 外国专利> OPIOID ANALGESICS AND 3-HYDROXYACETANILIDE FOR TREATING PAIN

OPIOID ANALGESICS AND 3-HYDROXYACETANILIDE FOR TREATING PAIN

机译：阿片类止痛药和3-羟基乙酰胺治疗疼痛

页面导航

摘要
著录项
相似文献

摘要

Pharmaceutical combinations of opioid analgesics and analgesics that act through non-opioid mechanisms are commonly used to provide pain relief. An example of this pharmaceutical combination is the product Vicodin™, where the opioid analgesic is hydrocodone and the non-opioid is acetaminophen. However, liver toxicity from the acetaminophen component is common. The invention provides an improvement over the opioid and acetaminophen pharmaceutical combinations for the management of pain by the concomitant administration of an opioid analgesics and the non-opioid analgesic 3-hydroxyacetanilide. This combination has been found to exhibit unexpectedly enhanced analgesic activity when dosed orally in a mammal.

机译：阿片类镇痛药和通过非阿片类药物机制起作用的镇痛药的药物组合通常用于缓解疼痛。这种药物组合的一个例子是产品Vicodin™，其中阿片类镇痛药是氢可酮，非阿片类药物是对乙酰氨基酚。然而，对乙酰氨基酚成分引起的肝毒性是常见的。通过同时给予阿片类镇痛药和非阿片类镇痛药3-羟基乙酰苯胺，本发明提供了对阿片类药物和对乙酰氨基酚药物组合的用于疼痛控制的改进。已经发现当在哺乳动物中口服给药时，该组合表现出出乎意料的增强的镇痛活性。

著录项

公开/公告号US2014378496A1

专利类型
公开/公告日2014-12-25

原文格式PDF
申请/专利权人 SLX PHARMACEUTICALS LLC;
展开▼

申请/专利号US201214357731
发明设计人 JONATHAN WRAY;
展开▼

申请日2012-11-09
分类号A61K31/485;A61K31/167;
国家 US
入库时间 2022-08-21 15:22:02

相似文献

专利
外文文献
中文文献