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Hexamethonium Reverses the Lethal Cardiopulmonary Damages in a Rat Model of Brain Stem Lesions Mimicking Fatal Enterovirus 71 Encephalitis
Hexamethonium Reverses the Lethal Cardiopulmonary Damages in a Rat Model of Brain Stem Lesions Mimicking Fatal Enterovirus 71 Encephalitis
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机译：Hexamethonium逆转致命性肠病毒71型脑炎的脑干病变大鼠模型中的致命性心肺损伤。
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摘要
Disclosed is a method for inhibiting the excessive release of catecholamines of mammals infected by the enterovirus 71 (EV71), and more specially, a method for reversing the cardiopulmonary damages caused from EV71 infection in an animal model by using hexamethoniums. An early administration of a suitable amount of hexamethonium to the rats mimicking enterovirus 71 infection will attenuate the acute excessive release of catecholamines in the body of each rat. Thus, cardiac dysfunction and pulmonary edema generally caused by EV71 encephalitis is prevented and the survival rate of the rats increases.
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