首页> 外国专利> COMPOSITIONS AND METHODS FOR THE TREATMENT OF CANCERS ASSOCIATED WITH A DEFICIENCY IN THE MRE11/RAD50/NBS1 DNA DAMAGE REPAIR COMPLEX

COMPOSITIONS AND METHODS FOR THE TREATMENT OF CANCERS ASSOCIATED WITH A DEFICIENCY IN THE MRE11/RAD50/NBS1 DNA DAMAGE REPAIR COMPLEX

机译：用于治疗MRE11 / RAD50 / NBS1 DNA损伤修复复合物缺乏症的癌症的组合物和方法

页面导航

摘要
著录项
相似文献

摘要

Provided are compositions and methods for the identification and treatment of cancers exhibiting reduced MRE11/RAD50/NBS1 (MRN) complex formation and/or functionality as well as methods for the identification and use of cytotoxic agents, including clastogenic agents, for the treatment of cancers exhibiting reduced MRN complex formation and/or functionality. Also provided are methods for detecting and treating cancers, in particular breast cancers, such as hormone-negative breast cancers (HNBCs) and triple-negative breast cancers (TNBCs), colorectal cancers, urothelial cancers, and other cancers that exhibit reduced MRN complex formation and/or functionality and are correspondingly sensitive to growth and/or survival inhibition by one or more cytotoxic agents.

机译：提供了鉴定和治疗表现出减少的MRE11 / RAD50 / NBS1（MRN）复合物形成和/或功能的癌症的组合物和方法，以及鉴定和使用用于治疗癌症的细胞毒性剂（包括裂解酶）的方法表现出减少的MRN复合物形成和/或功能。还提供了用于检测和治疗癌症的方法，特别是乳腺癌，例如激素阴性乳腺癌（HNBC）和三阴性乳腺癌（TNBCs），结直肠癌，尿路上皮癌和其他表现出MRN复杂形成减少的癌症和/或功能性，并且相应地对一种或多种细胞毒性剂的生长和/或存活抑制敏感。

著录项

公开/公告号US2015313922A1

专利类型
公开/公告日2015-11-05

原文格式PDF
申请/专利权人 SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH;
展开▼

申请/专利号US201314647806
发明设计人 JOHN H.J. PETRINI;GAORAV P. GUPTA;
展开▼

申请日2013-11-27
分类号A61K31/675;A61K31/196;A61K33/04;A61K31/198;A61K31/4745;A61K31/282;A61K33/24;A61K31/407;A61K31/513;A61K31/704;A61K45/06;G01N33/574;G01N33/50;A61N5/10;A61K31/131;
国家 US
入库时间 2022-08-21 15:25:33

相似文献

专利
外文文献
中文文献