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SENSITIZATION OF CANCER CELLS TO DNA DAMAGE BY INHIBITING KINASES ESSENTIAL FOR DNA DAMAGE CHECKPOINT CONTROL

机译:通过抑制基本的激酶损伤点控制激酶来使癌细胞对DNA损伤的敏感性

摘要

The invention provides methods for overriding cell cycle arrest in a tumor cell, which comprise inducing DNA damage in the cell, and contacting the cell with an amount of bosutinib or a bosutinib isomer effective to inhibit one or more kinase constituents of a DNA damage checkpoint pathway. The invention also provides novel bosutinib isomers, as well as compositions of the novel isomers and the bosutinib isomer 3,5-dichloro-4-methoxyaniline.
机译:本发明提供了用于覆盖肿瘤细胞中细胞周期停滞的方法,该方法包括在细胞中诱导DNA损伤,并使细胞与有效抑制DNA损伤检查点途径的一种或多种激酶成分的一定量的bosutinib或bosutinib异构体接触。 。本发明还提供了新的波舒替尼异构体,以及该新的异构体和波舒替尼异构体3,5-二氯-4-甲氧基苯胺的组成。

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