首页> 外国专利> METHOD OF ENHANCING GLUCOSE-STIMULATED INSULIN SECRETION AND OF TREATING TYPE 2 DIABETES OR HYPOGLYCEMIA

METHOD OF ENHANCING GLUCOSE-STIMULATED INSULIN SECRETION AND OF TREATING TYPE 2 DIABETES OR HYPOGLYCEMIA

机译：增强葡萄糖刺激的胰岛素分泌和治疗2型糖尿病或低血糖的方法

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摘要

The present invention is directed to a method of enhancing glucose-stimulated insulin secretion in a subject. The method involves selecting a subject with: (1) an antioxidant deficiency and (2) a need for enhanced glucose-stimulated insulin secretion, and administering to the selected subject an agent selected from the group consisting of (1) a compound according to Formula I or a pharmaceutically acceptable salt thereof:; embedded image

;wherein the substituents R¹-R³, X, Y, and n are as described herein, (2) glutathione peroxidase, or (3) activators of PGC-1α antioxidant response element, under conditions effective to enhance glucose-stimulated insulin secretion in the subject. The present invention also relates to methods of treating a subject with Type 2 diabetes and treating a subject with hypoglycemia by administering these agents.

机译：本发明涉及在受试者中增强葡萄糖刺激的胰岛素分泌的方法。该方法包括选择具有以下方面的受试者：（1）抗氧化剂缺乏和（2）需要增强葡萄糖刺激的胰岛素分泌，以及向所选择的受试者施用选自由以下组成的组的试剂：（1）根据下式的化合物I或其药学上可接受的盐： “嵌入式图像”

;其中取代基R ^{1 -R ^{3 ，X，Y和n如本文所述，（2）谷胱甘肽过氧化物酶，或（3）PGC-1α活化剂抗氧化剂反应元件，在有效增强受试者的葡萄糖刺激的胰岛素分泌的条件下。本发明还涉及通过施用这些药剂来治疗患有2型糖尿病的受试者和患有低血糖症的受试者的方法。}}

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公开/公告号US2015297564A1

专利类型
公开/公告日2015-10-22

原文格式PDF
申请/专利权人 XINGEN LEI;
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申请/专利号US201514691213
发明设计人 XINGEN LEI;
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申请日2015-04-20
分类号A61K31/41;A61K38/44;
国家 US
入库时间 2022-08-21 15:27:21

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