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The substituted 1-alkyl-thin Bruno phosphorus -4 (1H) - one derivatives, their preparation and their therapeutic application

机译:取代的1-烷基稀布鲁诺磷-4(1H)-一种衍生物,其制备及治疗应用

摘要

The subject of the present invention is compounds corresponding to the formula (I) in which: X represents a divalent (C2-C5)alkylene radical which is unsubstituted or substituted one or more times by an Alk group; R1 represents a phenyl, a naphthyl, a pyridyl, a 1-benzothienyl or a 1,3-benzodioxolyl; R2 represents a hydrogen atom, a halogen atom, an Alk group, an OAlk group or else a group chosen from S-Alk, SO-Alk, SO2-Alk, CON(R4)-Alk, N(R4)SO2-Alk, N(R4)CO-Alk, N(R4)SO2N(Alk)2; R3 represents a hydrogen atom, a halogen atom, an Alk group or an OAlk group; R4 represents a hydrogen atom or a (C1-C4)alkyl; Alk represents an unsubstituted or substituted (C1-C4)alkyl. Preparation process and therapeutic application.
机译:本发明的主题是对应于式(I)的化合物,其中:X表示未被取代或被Alk基团取代一次或多次的二价(C2-C5)亚烷基。 R1代表苯基,萘基,吡啶基,1-苯并噻吩基或1,3-苯并二氧戊基; R 2代表氢原子,卤素原子,Alk基团,OAlk基团或选自S-Alk,SO-Alk,SO2-Alk,CON(R4)-Alk,N(R4)SO2-Alk的基团, N(R4)CO-Alk,N(R4)SO2N(Alk)2; R3代表氢原子,卤素原子,Alk基或OAlk基; R4代表氢原子或(C1-C4)烷基; Alk代表未取代或取代的(C 1 -C 4)烷基。制备过程和治疗应用。

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