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Gene transfer into airway epithelial stem cells using lentiviral vectors pseudotyped with RNA or DNA virus spike proteins
Gene transfer into airway epithelial stem cells using lentiviral vectors pseudotyped with RNA or DNA virus spike proteins
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机译:使用用RNA或DNA病毒刺突蛋白假型化的慢病毒载体将基因转移到气道上皮干细胞中
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摘要
The present inventors successfully introduced genes into stem cells of airway epithelial tissues using simian immunodeficiency virus vectors pseudotyped with F and HN, which are envelope glycoproteins of Sendai virus. Gene transfer into airway epithelial tissue stem cells using a vector of the present invention is useful for gene therapy of genetic respiratory diseases such as cystic fibrosis. Furthermore, it is possible to select respiratory organs such as the lungs as production tissues for providing proteins that are deficient due to genetic diseases.
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