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Use and application of lipid complexes in cystic fibrosis

机译:脂质复合物在囊性纤维化中的应用和应用

摘要

This invention provides for the use of compounds represented by the structure of the general formula (A): wherein L is a lipid or a phospholipid, Z is either nothing, ethanolamine, serine, inositol, choline, or glycerol, Y is either nothing or a spacer group ranging in length from 2 to 30 atoms, X is a physiologically acceptable monomer, dimer, oligomer, or polymer, wherein X is a glycosaminoglycan; and n is a number from 1 to 1000, wherein any bond between L, Z, Y and X is either an amide or an esteric bond in treating a subject suffering from cystic fibrosis, reducing or delaying the mortality of a subject suffering from cystic fibrosis or ameliorating symptoms associated with cystic fibrosis.
机译:本发明提供了由通式(A)的结构表示的化合物的用途:其中L为脂质或磷脂,Z为无,乙醇胺,丝氨酸,肌醇,胆碱或甘油,Y为无或X是长度为2至30个原子的间隔基,X是生理上可接受的单体,二聚体,低聚物或聚合物,其中X是糖胺聚糖; n是1至1000的数字,其中L,Z,Y和X之间的任何键是酰胺或酯键,用于治疗患有囊性纤维化的受试者,从而降低或延迟患有囊性纤维化的受试者的死亡率或减轻与囊性纤维化有关的症状。

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