首页> 外国专利> METHOD OF DIFFERENTIAL MORPHOMETRIC DIAGNOSTICS OF ERYTHRODERMAL FORM OF MYCOSIS FUNGOIDES AND SYNDROME OF SKIN PSEUDOLYMPHOMA BY RELATIVE VOLUME OF EPIDERMIS AND MITOTIC INDEX OF EPIDERMAL CELLS

METHOD OF DIFFERENTIAL MORPHOMETRIC DIAGNOSTICS OF ERYTHRODERMAL FORM OF MYCOSIS FUNGOIDES AND SYNDROME OF SKIN PSEUDOLYMPHOMA BY RELATIVE VOLUME OF EPIDERMIS AND MITOTIC INDEX OF EPIDERMAL CELLS

机译：表皮细胞相对体积和表皮细胞分裂指数相对于胶体真菌的红皮病形态和皮肤假性肺炎综合征的鉴别诊断方法

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FIELD: medicine.;SUBSTANCE: to perform differential morphometric diagnostics of an erythrodermal form of mycosis fungoides and the syndrome of skin pseudolymphom performed are: histological analysis of the affected skin biopsy samples by a method of light microscopy, immunodifferentiation of infiltrate cells, additional morphometric analysis of basal keratinocytes in histological preparations of the affected skin biopsy samples. In case of the similar histological picture, described in case of erythrodermal form of mycosis fungoides and the syndrome of skin pseudolymphoma such as acanthosis, hyperkeratosis, parakeratosis, oedema and vasodilatation of the derma, lymphohistiocytic infiltrates, located in the upper third of the derma, similar immunophenotype of the infiltrate cells in case of erythrodermal form of mycosis fungoides and the syndrome of skin pseudolymphoma, represented by CD2+, CD3+, CD4+, CD5+, CD43+, CD45RO+ lymphocytes, morphometric analysis of all epidermis cells is performed. After that, the relative volume of epidermis and mitotic index of the epidermal cells are calculated. In case of increase of the relative volume of the epidermis by 2.2 and more times in comparison with the normal skin and an increase of the mitotic index of the epidermal cells by 2.7 times and more in comparison with the normal skin, erythrodermal form of mycosis fungoides is diagnosed, and in case of the unchanged relative volume of the epidermis and the mitotic index of the epidermal cells in comparison with the normal skin, the syndrome of skin pseudolymphoma is diagnosed.;EFFECT: acceleration and accuracy of differential diagnostics of the said forms of skin lymphomas, which makes it possible to select tactics of early adequate rational treatment of the patient.;2 tbl, 2 ex

机译：领域：医学;目的：对真菌样真菌的红皮形式和皮肤假淋巴综合征进行形态学鉴别诊断：通过光学显微镜对受影响的皮肤活检样品进行组织学分析，浸润细胞的免疫分化，其他形态计量学皮肤活检样本的组织学制备中基础角质形成细胞的分析如果组织学图片相似，则描述为真菌性真菌病的红皮形式和皮肤假性淋巴瘤综合征，例如棘皮病，角化过度，角化不全，皮肤水肿和血管扩张，淋巴组织细胞浸润，位于皮肤的上三分之一。对于以真菌样真菌的红皮形式和皮肤假性淋巴瘤综合征为特征的浸润细胞类似的免疫表型，以CD2 +，CD3 +，CD4 +，CD5 +，CD43 +，CD45RO +淋巴细胞为代表，对所有表皮细胞进行形态分析。之后，计算表皮的相对体积和表皮细胞的有丝分裂指数。如果表皮的相对体积比正常皮肤增加2.2倍或更多，而表皮细胞的有丝分裂指数比正常皮肤增加2.7倍或更多，则真菌病菌的红皮形式与正常皮肤相比，可诊断出表皮相对体积和表皮细胞的有丝分裂指数不变的情况下，可诊断出皮肤假淋巴瘤综合征;效果：所述形式的鉴别诊断的加速和准确性皮肤淋巴瘤的治疗，这使得可以选择对患者进行早期充分合理治疗的策略。; 2 tbl，2 ex

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公开/公告号RU2526180C1

专利类型
公开/公告日2014-08-20

原文格式PDF
申请/专利权人 GARIFULLINA ELMIRA FANISOVNA;
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申请/专利号RU20130138126
发明设计人 GARIFULLINA EHLMIRA FANISOVNA;TUKHVATULLINA ZULFIJA GABIDULLAEVNA;KHISMATULLINA ZAREMA RIMOVNA;
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申请日2013-08-14
分类号G01N33/483;G01N33/53;
国家 RU
入库时间 2022-08-21 15:38:24

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