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METHOD FOR PREDICTION OF PROGRESSION OF DIABETIC RETINOPATHY AND DIABETIC MACULAR OEDEMA

机译：预测糖尿病视网膜病变和糖尿病性黄斑水肿进展的方法

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FIELD: medicine.;SUBSTANCE: blood plasma glycated haemoglobin and lachrymal vascular endothelial growth factor VEGF are measured by enzyme-linked immunosorbent assay. There are derived a criterion R1 characterising an intensity of the macular oedema; a criterion R2 characterising a degree of sensitivity threshold shift; a criterion R3 reflecting a character of relations of retinal morphological structures describing an intensity of the oedema as shown by the criterion R1, and a degree of diabetes mellitus compensation; criterion R4 reflecting the relation of the retinal morphological structures as shown by the criterion R1 and VEGF. The correlated relations of the criteria R1-R4 provide a basis to calculate Rcom that is an integral criterion of progression reflecting the developmental character and a risk of progression of diabetic retinopathy (DRP) and diabetic macular oedema (DMO). If Rcom≤0.07, a neuroproliferative stage is diagnosed, and a low risk of progression of DRP and DMO is predicted. If 0.07Rcom0.18, a pre-proliferative stage is diagnosed, and a high risk of progression of DRP and DMO is predicted. The values within 0.18≤Rcom≤1.0 enables diagnosing a proliferative stage, and a high risk of progression of DRP and DMO with an unfavourable outcome for vision is predicted.;EFFECT: method provides an objective quantitative assessment of a risk of development and progression of DRP with DMO, presenting an entire aspect of the disease, including morphological and functional changes of the central retina determining a visual acuity, an effect of VEGF on DRP and DMO pathogenesis, a degree of diabetes mellitus compensation.;11 dwg, 2 ex

机译：领域：药物;研究对象：通过酶联免疫吸附法测定血浆糖化血红蛋白和泪液血管内皮生长因子VEGF。得出了表征黄斑水肿强度的标准R1。表征灵敏度阈值偏移程度的标准R2;反映视网膜形态结构的关系的标准R3描述了标准R1所示的水肿的强度，以及糖尿病的补偿程度;如标准R1和VEGF所示，标准R4反映了视网膜形态结构的关系。标准R1-R4的相关关系提供了计算Rcom的基础，Rcom是反映糖尿病性视网膜病变（DRP）和糖尿病性黄斑水肿（DMO）的发展特征和发展风险的整体进展标准。如果Rcom≤0.07，则诊断为神经增生期，并预测DRP和DMO进展的风险较低。如果0.07

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公开/公告号RU2520826C1

专利类型
公开/公告日2014-06-27

原文格式PDF
申请/专利权人 GOSUDARSTVENNOE BJUDZHETNOE OBRAZOVATELNOE UCHREZHDENIE DOPOLNITELNOGO PROFESSIONALNOGO OBRAZOVANIJA ROSSIJSKAJA MEDITSINSKAJA AKADEMIJA POSLEDIPLOMNOGO OBRAZOVANIJA MINISTERSTVA ZDRAVOOKHRANENIJA ROSSIJSKOJ FEDERATSII (GBOU DPO RMAPO MINZDRAVAROSSII);
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申请/专利号RU20130106360
发明设计人 MOSHETOVA LARISA KONSTANTINOVNA;VOROBEVA IRINA VITALEVNA;MERKUSHENKOVA DARJA ALEKSANDROVNA;PODGUZOV GENNADIJ VASILEVICH;ALEKHNOVICH VALENTIN IVANOVICH;
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申请日2013-02-14
分类号A61B3/06;A61B3/00;G01N33/49;
国家 RU
入库时间 2022-08-21 15:38:28

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