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METHOD FOR PREDICTION OF HYPERTENSION COMPLICATIONS OF PREGNANCY IN PATIENTS SUFFERING FROM GESTATIONAL DIABETES MELLITUS

机译:预测妊娠糖尿病患者妊娠高血压并发症的方法

摘要

FIELD: medicine.;SUBSTANCE: method is based on measuring the following parameters: AGT gene 704C version allele: (704TC or 704CC genotype), AGT gene 521T version allele (521CT or 521TT genotype), AGTR1 gene 1166C version allele (1166AC or 1166CC genotype), NOS3 gene 786C version allele (786TC or 786 CC genotype). There are also specified: the age of 35 and older, a bid foetus in past medical history, a patient's BWI ≥40 kg/m2, cardiovascular pathologies in relatives. That is followed by calculating a prognostic index by the formula: P=0.861 × X1+0.636 × X2+0.271 × X3+0.793 × X4+1.487 × X5+0.822 × X6+0.869 × X7+0.801 × X8 - 2.421, wherein X1 is AGT gene C allele (polymorphism 704 TC) in the genotype (yes -1, no - 0). X2 is AGT gene T allele (polymorphism 521 CT) in the genotype (yes -1, no - 0). X3 is AGT gene T allele (polymorphism 1166 CT) in the genotype (yes -1, no - 0). X4 is NOS3 gene C allele (polymorphism 786 CT) in the genotype (yes -1, no - 0). X5 is the age of 35 and older (yes -1, no - 0). X6 is a big foetus in past medical history (yes -1, no - 0). X7 is the patient's BWI 40 kg/m (if 40 kg/m -1, if not - 0). X8 is a cardiovascular pathology in relatives (yes -1, no - 0). Const=-2.42129. If P0, no risk of developing hypertension complications is stated. If P0, developing hypertension complications are predicted.;EFFECT: invention has high sensitivity, specificity, and efficiency; this formula enables predicting developing hypertension complications prior to clinical manifestations.;2 ex
机译:领域:医学;实体:方法基于测量以下参数:AGT基因704C版等位基因:(704TC或704CC基因型),AGT基因521T版等位基因(521CT或521TT基因型),AGTR1基因1166C版等位基因(1166AC或1166CC)基因型),NOS3基因786C版等位基因(786TC或786 CC基因型)。还规定:35岁及以上,既往病史中的胎儿,患者的BWI≥40 kg / m 2 ,亲属的心血管疾病。然后通过以下公式计算预后指标:P = 0.861×X1 + 0.636×X2 + 0.271×X3 + 0.793×X4 + 1.487×X5 + 0.822×X6 + 0.869×X7 + 0.801×X8-2.421,其中X1是基因型(是-1,否-0)中的AGT基因C等位基因(多态性704 T> C)。 X2是基因型(是-1,否-0)中的AGT基因T等位基因(多态性521 C> T)。 X3是基因型(是-1,否-0)中的AGT基因T等位基因(多态性1166 C> T)。 X4是基因型(是-1,否-0)中的NOS3基因C等位基因(多态性786 C> T)。 X5是35岁以上的年龄(是-1,否-0)。 X6是过去医学史上的大胎儿(是-1,否-0)。 X7是患者的BWI> 40 kg / m(如果> 40 kg / m -1,否则-0)。 X8是亲属的心血管疾病(是-1,否-0)。常数= -2.42129。如果P <0,则表明没有发生高血压并发症的风险。如果P> 0,则预示着正在发生的高血压并发症。效果:本发明具有很高的敏感性,特异性和效率。该公式可以在临床表现出现之前预测高血压并发症的发生; 2 ex

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