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METHOD OF TREATING SLOW METHOTREXATE ELIMINATION FOLLOWING HIGH-DOSE INFUSION ACCOMPANYING CEREBRAL TUMOURS IN CHILDREN
METHOD OF TREATING SLOW METHOTREXATE ELIMINATION FOLLOWING HIGH-DOSE INFUSION ACCOMPANYING CEREBRAL TUMOURS IN CHILDREN
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机译：伴有脑肿瘤的高剂量输注治疗慢速氨甲蝶呤的方法
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FIELD: medicine.;SUBSTANCE: dose of leucovorin is determined 24 hours after the 24-hour infusion of methotrexate and further every 6 hours depending on the concentration of blood serum methotrexate, and a time from the beginning of the 24-hour infusion of methotrexate in a dose of 5 g/m2, as follows: if the concentration of blood serum methotrexate is ≥151 µmole/l 24 hours after the beginning of the infusion, a dose of leucovorin makes 100 mg/m2, 30-42 hours after the infusion - 200 mg/m2, 48 hours and more after the infusion - 2,000 mg/m2; if the concentration of methotrexate is 101-150 µmole/l 24 hours after the beginning of the infusion, leucovorin is not administered, 30-54 hours after the beginning of the infusion, a dose of leucovorin makes 200 mg/m2, 60 hours and more after the infusion - 2,000 mg/m2; if the concentration of methotrexate is 21-100 µmole/l 24 hours after the beginning of the infusion, leucovorin is not administered, 30 hours after the beginning of the infusion, a dose of leucovorin makes 15 mg/m2, 36-66 hours - 30 mg/m2; 72 hours and more - 200 mg/m2; if the concentration of methotrexate is 4-20 µmole/l 24-30 hours after the beginning of the infusion, leucovorin is not administered, 36-66 hours after the beginning of the infusion, a dose of leucovorin makes 15 mg/m2, 72 hours and more - 30 mg/m2; if the concentration of methotrexate is 0.2-3.9 µmole/l 24-42 hours after the beginning of the infusion, leucovorin is not administered, 48 hours and more after the beginning of the infusion, a dose of leucovorin makes 15 mg/m2; leucovorin is administered until the concentration of blood serum makes not less than 0.2 µmole/l.;EFFECT: method enables reducing a toxic effect of methotrexate on the body by selecting an optimum individual dose of leucovorin.;1 dwg, 2 tbl, 1 ex
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机译：领域：药物;实体：根据甲氨蝶呤的血清浓度以及从甲氨蝶呤开始24小时输注开始的时间，每24小时确定甲氨蝶呤的剂量，然后每6小时确定一次。剂量为5 g / m 2 时，如下所示：如果在开始输注后24小时，血清甲氨蝶呤的浓度≥151µmole / l，则亚叶酸剂量为100 mg / m 2 ，输液后30-42小时-200 mg / m 2 ，输液后48小时及以上-2,000 mg / m 2 ;如果甲氨蝶呤的浓度在输注开始后24小时为101-150 µmole / l，则在输注开始后30-54小时不给予亚叶酸钙，则亚叶酸钙的剂量为200 mg / m 2 ，输注后60小时或更长时间-2,000 mg / m 2 ;如果甲氨蝶呤的浓度在开始输注后24小时为21-100 µmole / l，则不使用亚叶酸。在输注开始后30小时，亚叶酸的剂量为15 mg / m 2 ，36-66小时-30 mg / m 2 ; 72小时以上-200 mg / m 2 ;如果甲氨蝶呤的浓度在输注开始后24-30小时为4-20 µmole / l，则不给予亚叶酸，在输注开始后36-66小时，亚叶酸的剂量为15 mg / m 2 ，需要72小时以上-30 mg / m 2 ;如果甲氨蝶呤的浓度在输注开始后24-42小时为0.2-3.9 µmole / l，则在输注开始后48小时或更长时间不给予亚叶酸钙，则亚叶酸钙剂量为15 mg / m 2 ;施用亚叶酸钙直至血清浓度不低于0.2 µmole / l。效果：该方法可通过选择最佳的亚叶酸钙素单剂量来降低甲氨蝶呤对人体的毒性作用。; 1 dwg，2 tbl，1 ex
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